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首页> 外文期刊>Journal of nano research >PEG Functionalized Gold Nanoparticle loaded PLGA Films for Drug Delivery
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PEG Functionalized Gold Nanoparticle loaded PLGA Films for Drug Delivery

机译：PEG官能化金纳米颗粒负载PLGA膜用于药物输送

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摘要

A novel composite of poly(ethylene glycol) (PEG) functionalized gold nanoparticles (AuNP-PEG) dispersed within Poly(lactic-go-glycolic) (PLGA) films, were prepared to demonstrate the concept of a combined targeted and sustained implant material. This technology offers the promise of improved therapies for difficult to treat tumors such as Gliomas. Gold nanoparticles (AuNPs) synthesized via a modified Turkevich method, were functionalized with thiol terminated polyethylene glycol (PEG), washed using centrifugation, dried, re-suspended in a solution of PLGA in dichloromethane and finally vacuum dried to produce the solvent cast films. The degradation and nanoparticle release profile of these films were studied by immersion in PBS media at 37 ℃ over period's of up-to 58 days. Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) was conducted. The release of the AuNPs-PEG nanoparticles during degradation was studied using inductively coupled plasma mass spectroscopy (ICP-MS). It was observed that the AuNP-PEG nanoparticles were individually dispersed within the PLGA and that their addition extended the degradation time of the PLGA film, but did not appear to alter the nature of degradation. The nanoparticle release from the composite films displayed an approximately zero-order release profile.
机译：制备了分散在聚乳酸-乙醇酸（PLGA）薄膜中的新型聚乙二醇（PEG）功能化金纳米颗粒（AuNP-PEG）复合材料，以证明靶向和持续植入材料的组合概念。这项技术为改善难以治疗的神经胶质瘤等肿瘤的治疗方法提供了希望。通过改良的Turkevich方法合成的金纳米颗粒（AuNPs）用巯基封端的聚乙二醇（PEG）进行功能化，通过离心洗涤，干燥，重新悬浮在PLGA的二氯甲烷溶液中，最后真空干燥以生产溶剂流延膜。通过将膜浸入PBS介质中于37℃下长达58天的时间，研究了这些膜的降解和纳米颗粒释放特性。进行了热重分析（TGA），差示扫描量热法（DSC），扫描电子显微镜（SEM）和衰减全反射傅里叶变换红外光谱（ATR-FTIR）。使用电感耦合等离子体质谱法（ICP-MS）研究了AuNPs-PEG纳米粒子在降解过程中的释放。观察到AuNP-PEG纳米颗粒分别分散在PLGA内，并且它们的添加延长了PLGA膜的降解时间，但是似乎没有改变降解的性质。从复合膜释放的纳米颗粒显示出近似零级的释放曲线。

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  • 来源
    《Journal of nano research》 |2014年第2014期|83-94|共12页
  • 作者

    D. Dixon; B.J. Meenan; J. Manson;

  • 作者单位

    Nanotechnology and Integrated Bioengineering Centre, University of Ulster, Jordanstown, Shore Road, Newtownabbey, BT37 0QB, Northern Ireland, UK;

    Nanotechnology and Integrated Bioengineering Centre, University of Ulster, Jordanstown, Shore Road, Newtownabbey, BT37 0QB, Northern Ireland, UK;

    Nanotechnology and Integrated Bioengineering Centre, University of Ulster, Jordanstown, Shore Road, Newtownabbey, BT37 0QB, Northern Ireland, UK;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Gold nanoparticles; thiolated polyethylene glycol; PEG; PLGA poly(lactide-co-glycolide); bioabsorbable; drug delivery;

    机译：金纳米粒子;硫醇化聚乙二醇PEG;PLGA聚（丙交酯-乙交酯）;可生物吸收的药物输送;

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