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首页> 外文期刊>Journal of Nanoparticle Research >Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues
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Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues

机译：连续光学相干断层扫描监测生物组织中纳米颗粒的积累

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In this study, dynamics of nanoparticles penetrating and accumulating in biotissue (healthy skin) was investigated in vivo by the noninvasive method of optical coherence tomography (OCT). Gold nanoshells and titanium dioxide nanoparticles were studied. The processes of the nanoparticles penetration and accumulation in biotissue are accompanied by the changes in optical properties of skin which affect the OCT images. The continuous OCT monitoring of the process of the nanoparticles penetration into skin showed that these changes appeared in 30 min after application of nanoparticles on the surface; the time of accumulation of maximal nanoparticles concentration in skin was observed in period of 1.5–3 h after application. Numerical processing of the OCT signal exhibited the increase in contrast between upper and lower parts of dermis and contrast decay of the hair follicle border during 60–150 min. The transmission electron microscopy technique confirmed accumulation of the both types of nanoparticles in biotissue. The novelty of this study is presentation of OCT ability to in vivo monitor dynamics of nanoparticles penetration and their re-distribution within living tissues.
机译：在这项研究中，通过光学相干断层扫描（OCT）的非侵入性方法研究了纳米粒子在生物组织（健康皮肤）中渗透和积累的动力学。研究了金纳米壳和二氧化钛纳米颗粒。纳米粒子在生物组织中的渗透和积累过程伴随着影响OCT图像的皮肤光学特性的变化。连续的OCT监测纳米粒子渗透到皮肤的过程表明，这些变化在纳米粒子应用到表面后的30分钟内出现。涂抹后1.5–3小时内观察到最大纳米颗粒浓度在皮肤中累积的时间。 OCT信号的数值处理显示，在60-150分钟内，真皮上部和下部之间的对比度增加，毛囊边界的对比度衰减。透射电子显微镜技术证实了两种类型的纳米颗粒在生物组织中的积累。这项研究的新颖性在于OCT能够在体内监测纳米颗粒渗透的动力学及其在活组织内的重新分布的能力。

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