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首页> 外文期刊>Journal of Neuroimmune Pharmacology >Nanoformulated Antiretroviral Drug Combinations Extend Drug Release and Antiretroviral Responses in HIV-1-Infected Macrophages: Implications for NeuroAIDS Therapeutics
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Nanoformulated Antiretroviral Drug Combinations Extend Drug Release and Antiretroviral Responses in HIV-1-Infected Macrophages: Implications for NeuroAIDS Therapeutics

机译：纳米配方的抗逆转录病毒药物组合扩展了HIV-1感染的巨噬细胞的药物释放和抗逆转录病毒反应：对神经艾滋病治疗的意义。

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摘要

We posit that improvements in pharmacokinetics and biodistributions of antiretroviral therapies (ART) for human immunodeficiency virus type one-infected people can be achieved through nanoformulationed drug delivery systems. To this end, we manufactured nanoparticles of atazanavir, efavirenz, and ritonavir (termed nanoART) and treated human monocyte-derived macrophages (MDM) in combination therapies to assess antiretroviral responses. This resulted in improved drug uptake, release, and antiretroviral efficacy over monotherapy. MDM rapidly, within minutes, ingested nanoART combinations, at equal or similar rates, as individual formulations. Combination nanoART ingested by MDM facilitated individual drug release from 15 to 20 days. These findings are noteworthy as a nanoART cell-mediated drug delivery provides a means to deliver therapeutics to viral sanctuaries, such as the central nervous system during progressive human immunodeficiency virus type one infection. The work brings us yet another step closer to realizing the utility of nanoART for virus-infected people.
机译：我们认为，可以通过纳米制剂的药物递送系统来改善针对人类免疫缺陷病毒一型感染者的抗逆转录病毒疗法（ART）的药代动力学和生物分布。为此，我们制造了阿扎那韦，依非韦伦和利托那韦的纳米颗粒（称为nanoART），并结合联合治疗的人单核细胞衍生巨噬细胞（MDM）来评估抗逆转录病毒的反应。与单一疗法相比，这提高了药物的吸收，释放和抗逆转录病毒的疗效。 MDM可以在数分钟内以相同或相似的速率快速摄入nanoART组合，成为单个制剂。通过MDM摄入的nanoART的组合促进了15到> 20天的单个药物释放。这些发现是值得注意的，因为nanoART细胞介导的药物递送提供了一种在进行性人类免疫缺陷病毒一型感染期间将治疗剂递送至病毒保护区（例如中枢神经系统）的手段。这项工作使我们更进一步地实现了nanoART对于病毒感染者的效用。

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  • 来源
    《Journal of Neuroimmune Pharmacology》 |2010年第4期|p.592-601|共10页
  • 作者

    Ari S. Nowacek; JoEllyn McMillan; Reagan Miller; Alec Anderson; Barrett Rabinow; Howard E. Gendelman;

  • 作者单位

    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA;

    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA;

    Baxter Healthcare Corporation, Round Lake, IL, 60073, USA;

    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA;

    Baxter Healthcare Corporation, Round Lake, IL, 60073, USA;

    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA;

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  • 正文语种 eng
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  • 关键词

    antiretroviral therapy; nanoparticles; macrophages; drug delivery; HIV; nanomedicine;

    机译：抗逆转录病毒疗法;纳米颗粒;巨噬细胞;药物输送;HIV;纳米药物;

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