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首页> 外文期刊>Journal of Oleo Science >Preparing Glabridin-in-Water Nanoemulsions by High Pressure Homogenization with Response Surface Methodology
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Preparing Glabridin-in-Water Nanoemulsions by High Pressure Homogenization with Response Surface Methodology

机译：响应面法高压均质法制备水合皂苷纳米乳剂

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摘要

Glabridin is a pharmacological active hydrophobic pyranoisoflavan isolated from licorice. It has low bioavailability and solubility and therefore is difficult to apply for industry use. We investigated the effect of combining caprylic triglyceride with glabridin (2-6%, w/w), emulsifier (3-7%, w/w), and homogenization pressure (70-130 MPa) on the droplet size of glabridin nanoemulsions using response surface methodology by a 3-factor-3-level Box-Behnken design. Oil content, emulsifier content and pressure had a significant effect on droplet size (p < 0.05). The optimal conditions for preparing glabridin nanoemulsions were predicted to be caprylic triglyceride (oil content), 3.7%; emulsifier content, 5.3%, and homogenization pressure, 129 MPa.
机译：Glabridin是一种从甘草中分离出来的药理活性疏水性吡喃异黄酮。它的生物利用度和溶解度低，因此难以应用于工业用途。我们研究了将辛酸甘油三酸酯与格拉布丁（2-6％，w / w），乳化剂（3-7％，w / w）和均质化压力（70-130 MPa）组合对格拉布丁纳米乳剂液滴尺寸的影响响应面方法通过3因子3级Box-Behnken设计。油含量，乳化剂含量和压力对液滴尺寸有显着影响（p <0.05）。预计制备麦角蛋白纳米乳的最佳条件是辛酸甘油三酯（油含量）为3.7％。乳化剂含量为5.3％，均质压力为129 MPa。

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  • 来源
    《Journal of Oleo Science》 |2012年第9期|p.483-489|共7页
  • 作者

    Chang-Wei Hsieh; Po-Hsien Li; I-Chi Lu; Teng-Hsu Wang;

  • 作者单位

    Department of Medicinal Botany and Healthcare, Da-Yeh University (No. 168, University Rd., Dacun, Changhua 51591, Taiwan, Republic of China);

    Institute of Food Science and Technology, National Taiwan University, 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617, Republic of China);

    Department and Graduate Program of Biolndustry Technology, Da-Yeh University (No. 168, University Rd., Dacun, Changhua 51591, Taiwan,Republic of China);

    School of Pharmacy, National Defense Medical Center (No. 161, Sec. 6, Min-Chuan E. Rd., Taipei 104, Taiwan, Republic of China);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    glabridin; nanoemulsions; response surface methodology; high pressure homogenization;

    机译：加拉必丁纳米乳液响应面方法高压均质;

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