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首页> 外文期刊>Journal of End User Computing >Medication Use and the Risk of Newly Diagnosed Diabetes in Patients with Epilepsy: A Data Mining Application on a Healthcare Database
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Medication Use and the Risk of Newly Diagnosed Diabetes in Patients with Epilepsy: A Data Mining Application on a Healthcare Database

机译：癫痫患者的药物使用和新诊断糖尿病的风险：医疗数据库上的数据挖掘应用

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摘要

Epilepsy is a common neurological disorder that affects millions of people worldwide. Patients with epilepsy generally require long-term antiepileptic therapy and many of them receive polypharmacy. Certain medications, including older-generation antiepileptic drugs, have been known to predispose patients to developing diabetes. Although data mining techniques have become widely used in healthcare, they have seldom been applied in this clinical problem. Here, the authors used association rule mining to discover drugs or drug combinations that may be associated with newly diagnosed diabetes. Their findings indicate in addition to the most common culprits such as phenytoin and valproic acid, prescriptions containing carbamazepine, oxcarbazepine, or lamotrigine may be related to the development of newly diagnosed diabetes. These mined rules are useful as guidance to both clinical practice and future research.
机译：癫痫病是一种常见的神经系统疾病，影响着全球数百万人。癫痫患者通常需要长期的抗癫痫治疗，其中许多人接受多药治疗。已知某些药物，包括较老的抗癫痫药，会使患者更容易患上糖尿病。尽管数据挖掘技术已广泛应用于医疗保健中，但很少在此临床问题中应用。在这里，作者使用关联规则挖掘来发现可能与新诊断的糖尿病有关的药物或药物组合。他们的发现表明，除了苯妥英和丙戊酸等最常见的罪魁祸首之外，含有卡马西平，奥卡西平或拉莫三嗪的处方可能与新诊断的糖尿病有关。这些规则对于指导临床实践和未来研究很有用。

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  • 来源
    《Journal of End User Computing》 |2020年第2期|93-108|共16页
  • 作者

  • 作者单位

    Chiayi Christian Hosp Itmanson Med Fdn Chiayi Taiwan|Natl Chung Cheng Univ Informat Management Minxiong Taiwan;

    Natl Chung Cheng Univ Dept Informat Management Minxiong Taiwan;

    Tainan Sin Lau Hosp Tainan Taiwan|Natl Cheng Kung Univ Hosp Tainan Taiwan|Coll Med Tainan Taiwan;

    Natl Chung Cheng Univ Grad Inst Healthcare Informat Management Minxiong Taiwan;

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  • 正文语种 eng
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  • 关键词

    Antiepileptic Drug; Association Rules; Diabetes; Drug-Drug Interaction; Epilepsy;

    机译：抗癫痫药;关联规则;糖尿病;药物相互作用癫痫;

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