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首页> 外文期刊>Journal of Parasitology >THE ULTRASTRUCTURE OF THE PARASITOPHOROUS VACUOLE FORMED BY LEISHMANIA MAJOR
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THE ULTRASTRUCTURE OF THE PARASITOPHOROUS VACUOLE FORMED BY LEISHMANIA MAJOR

机译：以利什曼原虫为主要成分的PA虫卵的超微结构

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摘要

Protozoan parasites of Leishmania spp. invade macrophages as promastigotes and differentiate into replicative amastigotes within parasitophorous vacuoles. Infection of inbred strains of mice with Leishmania major is a well-studied model of the mammalian immune response to Leishmania species, but the ultrastructure and biochemical properties of the parasitophorous vacuole occupied by this parasite have been best characterized for other species of Leishmania. We examined the parasitophorous vacuole occupied by L. major in lymph nodes of infected mice and in bone marrow–derived macrophages infected in vitro. At all time points after infection, single L. major amastigotes were wrapped tightly by host membrane, suggesting that amastigotes segregate into separate vacuoles during replication. This small, individual vacuole contrasts sharply with the large, communal vacuoles occupied by Leishmania amazonensis. An extensive survey of the literature revealed that the single vacuoles occupied by L. major are characteristic of those formed by Old World species of Leishmania, while New World species of Leishmania form large vacuoles occupied by many amastigotes.
机译：利什曼原虫的原生动物寄生虫。作为前鞭毛体侵入巨噬细胞，并在寄生虫的液泡内分化成复制的变形虫。利什曼原虫感染的近交系小鼠感染是哺乳动物对利什曼原虫物种免疫应答的充分研究模型，但是该寄生虫所占据的寄生虫空泡的超微结构和生化特性已被其他利什曼原虫物种最好地表征。我们检查了被感染的小鼠的淋巴结和体外感染的骨髓源性巨噬细胞中大乳杆菌所占据的寄生虫空泡。在感染后的所有时间点，主要的L. amastigotes均被宿主膜紧紧包裹，表明在复制过程中amastigotes分离成单独的液泡。这种小的个体液泡与亚马逊利什曼原虫占据的大型公共液泡形成鲜明对比。大量的文献研究表明，由大利什曼原虫占据的单个液泡是利什曼原虫的旧世界物种形成的特征，而新世界的利什曼原虫物种形成了许多变形虫所占据的大液泡。

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