Responses of Leishmania (Viannia) braziliensis Cutaneous Infection to N-Methylglucamine Antimoniate in the Rhesus Monkey (Macaca mulatta) Model

A. Tevaa R. Porrozzia M. P. Oliveira-Netob and G. Grimaldi Jr.a

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Responses of Leishmania (Viannia) braziliensis Cutaneous Infection to N-Methylglucamine Antimoniate in the Rhesus Monkey (Macaca mulatta) Model

机译：猕猴模型中巴西利什曼原虫（Viannia）皮肤感染对N-甲基葡糖胺锑酸盐的反应

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The antileishmanial efficacy of the reference drug N-methylglucamine antimoniate (Glucantime®) was evaluated in groups of rhesus monkeys with acute and chronic Leishmania (Viannia) braziliensis cutaneous infection. The therapeutic responses in experimental animals to either a low dose (5 mg/kg body wt/day for 28 days) or a routine dose (20 mg/kg/day for 28 days) of pentavalent antimony were similar to those reported in the human disease. Primates were cured of their lesions after treatment, but with cryptic parasitism and/or relapse. The rhesus model of L. (V.) braziliensis cutaneous leishmaniasis therefore provides an additional resource for preclinical trials with newer drugs.

机译：在患有急性和慢性巴西利什曼原虫（Viannia）巴西皮肤病的恒河猴组中评估了参比药物N-甲基葡糖胺锑酸盐（Glucantime®）的抗疟疾功效。实验动物对五价锑低剂量（5 mg / kg体重/天，持续28天）或常规剂量（20 mg / kg /天，28天）的治疗反应与人类报道的相似疾病。治疗后灵长类动物的病变得以治愈，但伴有隐性寄生虫和/或复发。因此，巴西L.（V。）皮肤利什曼病的恒河猴模型为使用新药进行临床前试验提供了额外的资源。

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《Journal of Parasitology》 |2005年第4期|p.00000976-00000978|共3页
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A. Tevaa R. Porrozzia M. P. Oliveira-Netob and G. Grimaldi Jr.a;
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aDepartment of Immunology, Institute Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, Rio de Janeiro RJ, CEP 21045-900, Brazil bEvandro Chagas Clinical Research Institute, FIOCRUZ, Av. Brasil 4365, Rio de Janeiro RJ, CEP 21045-900, Brazil. grimaldi@ioc.fiocruz.br;

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Responses of Leishmania (Viannia) braziliensis Cutaneous Infection to N-Methylglucamine Antimoniate in the Rhesus Monkey (Macaca mulatta) Model

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