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首页> 外文期刊>Journal of Parasitology >EXACERBATION OF PLASMODIUM YOELII MALARIA IN ECHINOSTOMA CAPRONI INFECTED MICE AND ABATEMENT THROUGH ANTHELMINTIC TREATMENT
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EXACERBATION OF PLASMODIUM YOELII MALARIA IN ECHINOSTOMA CAPRONI INFECTED MICE AND ABATEMENT THROUGH ANTHELMINTIC TREATMENT

机译：约氏疟原虫疟疾在加倍棘皮CHI虫感染小鼠中的加重和通过杀虫剂治疗的清除

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摘要

The effect of chronic intestinal trematode infection on malaria was examined in a murine model of co-infection using Echinostoma caproni and Plasmodium yoelii. BALB/c mice (n = 32) infected with a low dose of E. caproni (10 cysts) 25–35 days before malaria infection displayed significantly increased malaria parasitemia (P = 0.01), extended patency of malaria (P = 0.03), and increased fatality (47%; P < 0.001) compared to mice infected only with P. yoelii (17X nonlethal strain) (n = 18). Further analysis revealed that differences in malaria parasitemia between fatal co-infections and infections with P. yoelii only were highly significant (P < 0.0001), whereas nonfatal co-infections were not statistically different. Exacerbation of malaria was demonstrated to be reversible through clearance of E. caproni worms by praziquantel treatment administered 10 days before malaria infection. No deaths were observed during malaria infection in mice cleared of their E. caproni infection (n = 10), and parasitemia was significantly reduced from that of untreated co-infected mice (P = 0.03) and was not different from that of mice infected with P. yoelii only. Further studies examining parasite-parasite interactions and host immune response in the echinostome model are warranted to understand the mechanisms affecting the course and outcome of malaria infection during concomitant helminth infection.
机译：在使用卡氏棘皮动物和约氏疟原虫的共感染的小鼠模型中检查了慢性肠道吸虫感染对疟疾的影响。疟疾感染发生前25-35天，用低剂量的卡波尼大肠杆菌（10个囊肿）感染的BALB / c小鼠（n = 32）显示出疟疾寄生虫病显着增加（P = 0.01），疟疾通畅时间延长（P = 0.03），与仅感染约氏疟原虫（17X非致死品系）的小鼠相比，死亡率增加（47％； P <0.001）（n = 18）。进一步的分析表明，致命的合并感染和约氏疟原虫感染之间的疟疾寄生虫病差异非常显着（P <0.0001），而非致命的合并感染在统计学上没有差异。通过在感染疟疾前10天进行吡喹酮治疗，可以清除卡普罗氏线虫，从而证明可逆转疟疾的恶化。在清除疟原虫后，未在疟疾感染过程中观察到死亡（n = 10），与未治疗的合并感染小鼠相比，寄生虫病明显减少（P = 0.03），与感染了该病的小鼠无异仅P. yoelii。在棘皮动物模型中检查寄生虫-寄生虫相互作用和宿主免疫反应的进一步研究值得了解，以了解在伴随蠕虫感染期间影响疟疾感染过程和结果的机制。

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    《Journal of Parasitology》 |2005年第4期|p.00000944-00000948|共5页
  • 作者

    Gregory S. Noland Thaddeus K. Graczyk Bernard Fried* Erik J. Fitzgerald† and Nirbhay Kumar;

  • 作者单位

    Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205. nkumar@jhsph.edu*Department of Biology, Lafayette College, Easton, Pennsylvania 18042†Center for Addiction and Pregnancy, Department of Gynecology and Obstetrics, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224;

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