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首页> 外文期刊>Journal of Parasitology >KINETICS OF THE INITIAL ROUNDS OF CELL DIVISION OF TOXOPLASMA GONDII
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KINETICS OF THE INITIAL ROUNDS OF CELL DIVISION OF TOXOPLASMA GONDII

机译：弓形虫细胞分裂初始圆的动力学

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摘要

RH strain Toxoplasma gondii tachyzoites that had naturally lysed their host cells were allowed to infect new host cells for a limited amount of time; subsequent parasite cell divisions were observed closely. On the basis of 4 independent trials, the estimated time to first cell division was 9.8 hr postinfection (PI) and was quite variable (95% confidence interval [CI]: 3.1–16.5 hr PI). The estimated time to second cell division was 14.9 hr PI and was less variable (95% CI: 12.1–17.7 hr PI). Few parasites divided before 6 hr PI in these 4 trials. When tachyzoites were derived by forced lysis (scraping an infected host cell culture and passing it through 27-gauge needles), the first parasite cell division occurred much more rapidly than had been observed in any of the trials with parasites derived by natural lysis. When parasites derived by forced lysis were held away from host cells for 3 hr PI, the first cell division was delayed in a manner similar to that seen in parasites derived by natural lysis. No differences were observed in the timing of the second cell division of parasites derived by forced lysis whether or not they had been held away from cells. These studies demonstrate that the conditions to which tachyzoites are exposed during transit from one host cell to another can affect the kinetics of parasite cell division in the new host cell.
机译：自然溶解其宿主细胞的RH株弓形虫速殖子可以在有限的时间内感染新的宿主细胞。密切观察随后的寄生虫细胞分裂。根据4项独立试验，首次细胞分裂的估计时间为感染后9.8小时（PI），并且变化很大（95％置信区间[CI]：3.1-16.5小时PI）。估计第二次细胞分裂的时间为14.9 hr PI，变化较小（95％CI：12.1–17.7 hr PI）。在这4个试验中，很少有寄生虫在感染前6小时分裂。当速殖子通过强迫裂解（刮除感染的宿主细胞培养物并使其经过27号针头）衍生时，与任何自然裂解的寄生虫试验相比，第一次寄生虫细胞分裂的发生速度要快得多。当通过强迫裂解产生的寄生虫在宿主细胞中停留3小时后，第一细胞分裂的延迟方式类似于自然裂解产生的寄生虫。在通过强迫裂解获得的寄生虫的第二次细胞分裂的时间上，没有观察到差异，无论它们是否远离细胞。这些研究表明，速殖子从一个宿主细胞转移到另一个宿主过程中所暴露的条件会影响新宿主细胞中寄生虫细胞分裂的动力学。

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  • 来源
    《Journal of Parasitology》 |2003年第5期|p.895-898|共4页
  • 作者

    Douglas B. Woodmansee;

  • 作者单位

    Department of Biology, Wilmington College, 251 Ludovic Street, Wilmington, Ohio 45177. doug_woodmansee@wilmington.edu;

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