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首页> 外文期刊>Journal of Polymers and the Environment >Biomass Derived Antimicrobial Hybrid Cellulose Hydrogel with Green ZnO Nanoparticles for Curcumin Delivery and its Kinetic Modelling
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Biomass Derived Antimicrobial Hybrid Cellulose Hydrogel with Green ZnO Nanoparticles for Curcumin Delivery and its Kinetic Modelling

机译：生物质衍生的具有绿色ZnO纳米颗粒的姜黄素递送抗菌杂化纤维素水凝胶及其动力学建模

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摘要

Regenerated cellulose obtained from sugarcane bagasse was used for hydrogel preparation using epichlorohydrin (crosslinker) and green zinc oxide nanoparticles (ZNPs) which were phytosynthesised from musk melon seed extract. The synthesised ZNPs were characterised using FESEM and EDAX. The swelling capacity of the hydrogel was determined by swelling measurements. For drug delivery studies from hydrogel, curcumin was selected as the model drug for its appealing anticancer and antimicrobial activity. The presence of ZNPs and curcumin in the hybrid hydrogel was analysed using FTIR, XRD, TGA and SEM analysis. The drug loading efficiency was optimised by Taguchi method. The drug release studies were performed under varying pH and initial drug loading concentration. The kinetic studies showed the best fit with case II type of transport with polymer swelling as the drug release mechanism. Antimicrobial activity for curcumin loaded hybrid hydrogel and pure cellulose hydrogel was performed using Staphylococcus aureus (bacteria) and Trichophyton rubrum (fungi). Thus, the developed curcumin loaded biomass derived hybrid hydrogel could find potential application towards skin infective applications.
机译：从甘蔗渣中获得的再生纤维素用于水凝胶制备，使用表氯醇（交联剂）和绿色氧化锌纳米颗粒（ZNP），它们是从麝香瓜种子提取物中进行植物合成的。使用FESEM和EDAX对合成的ZNP进行表征。通过溶胀测量确定水凝胶的溶胀能力。对于水凝胶的药物输送研究，姜黄素因其具有吸引力的抗癌和抗菌活性而被选作模型药物。使用FTIR，XRD，TGA和SEM分析了杂化水凝胶中ZNP和姜黄素的存在。田口法优化了载药效率。在不同的pH和初始载药浓度下进行了药物释放研究。动力学研究表明，以聚合物溶胀为药物释放机理，最适合案例II类型的运输。使用金黄色葡萄球菌（细菌）和毛癣菌（真菌）对载有姜黄素的杂化水凝胶和纯纤维素水凝胶进行抗菌活性。因此，开发的载有姜黄素的生物质衍生的杂化水凝胶可以在皮肤感染应用中找到潜在的应用。

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