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首页> 外文期刊>Journal of Polymers and the Environment >Gelatin/Gelatinized Sago Starch Biomembranes as a Drug Delivery System Using Rubber Latex as Plasticizer
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Gelatin/Gelatinized Sago Starch Biomembranes as a Drug Delivery System Using Rubber Latex as Plasticizer

机译：明胶/明胶西米淀粉生物膜作为使用橡胶胶乳作为增塑剂的药物输送系统

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摘要

Preparation and properties of gelatin and gelatin/gelatinized sago starch biomembranes as a drug delivery system are presented. Deproteinized natural rubber latex (DNRL) was chosen to blend as a plasticizer in biomembranes due to its elasticity. The opaque biomembranes were formed, and the effect of DNRL amounts (10-50 part per hundred of gelatin; phg) on mechanical properties of biomembranes was investigated. It was discovered that increasing the amounts of DNRL could decrease the brittleness of biomembranes. However, these DNRL blended biomembranes still swelled, dissolved in water, and eroded within 2 h. The 50 phg DNRL was further chosen for biomembrane preparations. Then, the 5-30 phg gelatinized sago starch which was prepared in-house was added. These gelatin/gelatinized sago starch biomembranes were homogenous and opaque. They portrayed good water uptake properties, and the highest values occurred in 20-30 min, then these biomembranes eroded slowly. Increasing the amounts of sago starch in biomembranes raised the water uptake rates but reduced the erosion properties. Biomembranes with and without starch blends showed the same tensile strengths. Their elongations at break increased when the amounts of starch were raised but still were lower than that of gelatin/DNRL biomembranes. The morphology, scanning electron microscopy, atomic force electron microscopy, Fourier transform infrared spectroscopy, differential scanning calorimeter, and X-ray diffractometer confirmed the compatibility of ingredients in biomembranes. Lidocaine and its hydrochloride salt were successfully incorporated in these biomembranes with good properties. The drug release and permeation of biomembrane showed good drug controlled release and were able to permeate through the pig skin.
机译：介绍了明胶和明胶/明胶西米淀粉生物膜作为药物递送系统的制备和性质。由于其弹性，选择了脱蛋白天然橡胶胶乳（DNRL）作为生物膜中的增塑剂。形成不透明的生物膜，并研究了DNRL量（每百份明胶中10-50份； phg）对生物膜的机械性能的影响。已经发现增加DNRL的量可以降低生物膜的脆性。但是，这些DNRL混合生物膜仍溶胀，溶于水，并在2小时内腐蚀。进一步选择50 phg DNRL用于生物膜制备。然后，添加内部制备的5-30 phg糊化西米淀粉。这些明胶/糊化的西米淀粉生物膜是均匀且不透明的。他们描绘了良好的吸水特性，最高值发生在20-30分钟内，然后这些生物膜慢慢腐蚀。生物膜中西米淀粉含量的增加提高了吸水率，但降低了侵蚀性能。具有和不具有淀粉共混物的生物膜显示出相同的抗张强度。当淀粉含量增加时，它们的断裂伸长率增加，但仍低于明胶/ DNRL生物膜的断裂伸长率。形态，扫描电子显微镜，原子力电子显微镜，傅立叶变换红外光谱，差示扫描量热仪和X射线衍射仪证实了生物膜中成分的相容性。利多卡因及其盐酸盐已成功掺入这些生物膜中，并具有良好的性能。药物的释放和生物膜的渗透显示出良好的药物控制释放，并且能够透过猪皮渗透。

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