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首页> 外文期刊>Journal of Polymers and the Environment >Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin
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Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin

机译：官能化食品级生物聚合物 - 纳米硅酸盐水凝胶作为芦丁持续递送装置

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摘要

Novel tamarind gum (TG) or carboxymethyl tamarind gum (CMTG) blended diethanolamine-functionalized pectin (DFP) based hydrogels reinforced with calcium silicate (CS) were developed for sustained delivery of rutin (RUT). The DFP (D-A, 48.7%) and CMTG (DS, 50.0%) were initially synthesized and analyzed through(1)H-NMR, FTIR, XRD and DSC studies. RUT-loaded hybrid hydrogels were subsequently afforded by Ca2+-induced gelation protocol. The hydrogels portrayed acceptable RUT entrapping efficiency (DEE, 29-43%), delayed eluting behaviour (Q(6h), 65-100%) and variable swelling at 6 h (16-172%), which were significantly influenced by formulation variables. The RUT dissolution profile of the optimized hydrogels (F-5) obeyed Korsmeyer-Peppas kinetic model with anomalous transport driven mechanism. These matrices also demonstrated excellent mucoadhesion property and biodegradability. Furthermore, the hydrogels revealed their smooth but distorted surface morphology and drug-carrier compatibility with attenuated RUT crystallinity. These hydrogels matrices were thus evidenced to be appropriate for the delivery of hydrophobic RUT in its solubilised form.
机译：开发出用硅酸钙（CS）增强硅酸钙（CS）增强的新型罗望胶（Tg）或羧甲基罗望胶（CMTG）混合二乙醇胺 - 官能化果胶（DFP）水凝胶，用于持续递送芦丁（RUT）。最初合成DFP（D-A，48.7％）和CMTG（DS，50.0％）通过（1）H-NMR，FTIR，XRD和DSC研究分析。随后通过Ca2 +诱导的凝胶化方案提供了载荷的混合水凝胶。水凝胶描绘了可接受的车辙诱捕效率（DEE，29-43％），延迟洗脱行为（Q（6h），65-100％）和可变肿胀在6小时（16-172％），这受到配方变量的显着影响。优化水凝胶（F-5）的RUT溶出谱遵守了具有异常运输驱动机制的Korsmeyer-Peppas动力学模型。这些基质还证明了优异的粘膜粘附性和生物降解性。此外，水凝胶显示出它们的光滑但扭曲的表面形态和药物 - 载体与减毒结晶性的相容性。因此，这些水凝胶基质被证明是适合于在其溶解的形式中递送疏水式车辙。

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