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首页> 外文期刊>Journal of Polymers and the Environment >Poly (Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems
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Poly (Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems

机译：聚（乳酸）-天冬氨酸共聚物：在药物输送系统中的可能用途

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摘要

The synthesis and characterization of poly(lactic acid)-co-aspartic acid copolymers (PLA-co-Asp) were presented. Subsequently, the synthesized PLA-co-Asp copolymers were tested as biodegradable carriers in drug delivery systems. PLA-co-Asp copolymers were synthesized by solution polycondensation procedure, using different molar ratios PLA/L-aspartic acid (2.33/1, 1/1, 1/2.33), manganese acetate and phosphoric acid as catalysts and N,N'-dimethyl formamide (DMF)/toluene as solvent mixture. The copolymers were characterized by FT-IR and ~1H-NMR spectros-copy, gel permeation chromatography (GPC), DSC and TG-DTG analyses. Diclofenac sodium, a non steroidal anti-inflammatory drug was subsequently loaded into PLA-co-Asp copolymers. The in vitro drug release experiments were done by dialysis of the copolymer/drug systems, in phosphate buffer solution (pH = 7.4, at 37 ℃) and monitored by UV spectroscopy.
机译：介绍了聚乳酸-天冬氨酸共聚物（PLA-co-Asp）的合成与表征。随后，将合成的PLA-co-Asp共聚物作为可生物降解的载体在药物递送系统中进行测试。采用不同的摩尔比PLA / L-天冬氨酸（2.33 / 1，1/1，1 / 2.33），醋酸锰和磷酸为催化剂，以N，N'-为原料，通过溶液缩聚法合成PLA-co-Asp共聚物。二甲基甲酰胺（DMF）/甲苯作为溶剂混合物。通过FT-IR和〜1H-NMR光谱，凝胶渗透色谱法（GPC），DSC和TG-DTG分析来表征共聚物。随后将非甾体抗炎药双氯芬酸钠装入PLA-co-Asp共聚物中。通过在磷酸盐缓冲液（pH = 7.4，在37℃）中对共聚物/药物体系进行透析来进行体外药物释放实验，并通过紫外光谱进行监测。

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