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Association of Birth Weight with Health and Long-Term Survival up to Middle and Old Ages in China

机译：中国的出生体重与健康和长期生存的关系

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摘要

This study is based on an unique dataset of birth records of 11,693 persons born in Beijing, China from 1921–54 and from clinical examinations (May 2003–April 2005) of 2,085 tracked surviving cohort members (aged 50–82) to diagnose seven major chronic diseases. Data were analyzed using the extended Fixed Attribute Dynamics (FAD) method and multivariate regressions. The results of our FAD analysis have shown that, as compared to the persons with low birth weight (2,500 g), the probability of survival from age 0 to ages 50–56, 63–67 and 68–82 for persons with higher birth weight (2,500–2,999 g, 3,000–3499 g, or ≥3,500 g) was 16–31, 62–104, and 52–108% higher respectively. These estimates display similar patterns for both genders, with somewhat stronger effects in men. Of the 27 estimates of the Odds Ratio of Survival in the FAD analysis, 21 are statistically significant. Controlling for 14 confounding factors, multivariate binary logistic regressions have demonstrated that the risk of having cardiovascular disease and diabetes is negatively associated birth weight; ordinal logit regressions have shown that the number of major chronic diseases at ages 50–82 is significantly associated with birth weight: the lower the birth weight, the higher the risk of having more chronic diseases. We conclude that low birth weight is negatively associated with 1) long-term survival probability from age 0 to ages 50–82, and 2) overall health at middle and old ages. Further research is needed to understand the mechanisms of these effects.
机译：这项研究基于1921年至54年在中国北京出生的11,693人的出生记录的独特数据集，以及对2085名追踪幸存的队列成员（50至82岁）进行临床检查（2003年5月至2005年4月），以诊断七个主要疾病慢性疾病。使用扩展的固定属性动态（FAD）方法和多元回归分析数据。我们的FAD分析结果表明，与低出生体重（<2,500克）的人相比，高出生人口从0岁到50-56、63-67和68-82岁的存活率重量（2,500–2,999 g，3,000–3499 g或≥3,500g）分别增加了16–31、62–104和52–108％。这些估计值显示出两种相似的模式，对男性的影响更大。在FAD分析中27个生存率的估计值中，有21个具有统计学意义。通过控制14个混杂因素，多元二元logistic回归表明，患有心血管疾病和糖尿病的风险与出生体重负相关；序数logit回归表明，50-82岁之间主要的慢性疾病的数量与出生体重显着相关：出生体重越低，患更多慢性疾病的风险越高。我们得出的结论是，低出生体重与1）从0岁到50-82岁的长期存活率和2）中老年人的总体健康状况负相关。需要进一步研究以了解这些作用的机制。

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  • 来源
    《Journal of Population Ageing》 |2010年第4期|p.143-159|共17页
  • 作者

    Yi Zeng; Zhenxin Zhang; Tao Xu; Zhongjie Fan; Xinhua Xiao; Xia Chen; Zishi Wang; Enling Ma; Danan Gu; Fengyu Zhang; Joseph M. Corless;

  • 作者单位

    Center for the Study of Aging and Human Development and Geriatrics Division, School of Medical, Duke University, Box 3003, Durham, NC, 27710, USA;

    Department of Neurology and Research Center for Clinical Epidemiology, Peking Union Medical College Hospital, Beijing, China;

    Department of Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China;

    Department of Cardiology, Peking Union Medical College Hospital, Beijing, China;

    Department of Endocrinology, Peking Union Medical College Hospital, Beijing, China;

    Department of Neurology and Research Center for Clinical Epidemiology, Peking Union Medical College Hospital, Beijing, China;

    Department of Cardiology, Peking Union Medical College Hospital, Beijing, China;

    Peking Union Medical College Hospital, Beijing, China;

    Center for the Study of Aging;

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  • 正文语种 eng
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  • 关键词

    Birth weight; Fetal growth, long-term survival; Chronic diseases, health; China;

    机译：出生体重;胎儿生长;长期存活;慢性病;健康;中国;

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