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首页> 外文期刊>Journal of soil & sediments >The dioRAMA project: assessment of dioxin-like activity in sediments and fish (Rutilus rutilus) in support of the ecotoxicological characterization of sediments
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The dioRAMA project: assessment of dioxin-like activity in sediments and fish (Rutilus rutilus) in support of the ecotoxicological characterization of sediments

机译：dioRAMA项目：评估沉积物和鱼类（Rutilus rut​​ilus）中二恶英样活性，以支持沉积物的生态毒理学表征

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Introduction Given the complex interactions of re-suspension processes and bioavailability of sediment-bound pollutants such as dioxin-like chemicals, there is need for a better inte-grative understanding of the cause-effect relationship of these pollutants. Currently, the majority of studies investigating potential risks of these chemicals only focus on characterizing sediment extracts via in vitro bioassays, thereby disregarding bioavailability, uptake, metabolism, and elimination rates of these compounds in vivo. To determine to which extent mechanism-specific effects in vitro reflect possible adverse effects in vivo, the research project dioRAMA, involving partnership between the Institute for Environmental Research of RWTH Aachen University and the Department Biochemistry/Ecotoxicology of the German Federal Institute of Hydrology, was established. Methods Animals from an elevated trophic level-common roach {Rutilus rutilus)-will be exposed to sediments from two major German rivers. Exposure will be performed in a system that enables a concurrent monitoring of environmental parameters. In parallel, in vitro studies will be conducted to determine dioxin-like potentials of sediment and fish extracts from the in vivo exposure experiments using different cell lines with varying endpoints. Moreover, extract fractionation procedures, using the strategy of effect-directed analysis, will enable the detection of specific contaminant groups responsible for the biological activity observed. Conclusion A closer interconnection between applied ecotoxicological science and regulatory needs will facilitate the improved assessment of dioxin-like compounds in sediment and biota. Consequently, this will enable their application in sediment management programs, which is one of the main goals of the dioRAMA project.
机译：引言鉴于重悬浮过程与诸如二恶英类化学品之类的沉积物结合污染物的生物利用度之间存在复杂的相互作用，因此需要对这些污染物的因果关系有更好的整体理解。当前，调查这些化学物质潜在风险的大多数研究仅集中于通过体外生物测定表征沉积物提取物，从而忽略了这些化合物在体内的生物利用度，吸收，代谢和清除率。为了确定体外机制特异性作用在多大程度上反映了体内可能的不良反应，研究项目dioRAMA由亚琛工业大学环境研究所与德国联邦水文学学院生物化学/生态毒理学系合作建立。成立。方法来自营养水平升高的动物-蟑螂（Rutilus rut​​ilus）-将暴露于两条德国主要河流的沉积物中。曝光将在能够同时监控环境参数的系统中执行。同时，将进行体外研究，从体内暴露实验中，使用具有不同终点的不同细胞系，确定沉积物和鱼提取物的二恶英样电位。此外，采用效果导向分析策略的提取物分级分离程序，将能够检测出负责观察到的生物活性的特定污染物基团。结论应用生态毒理学与法规需求之间的紧密联系将有助于改进沉积物和生物区系中二恶英样化合物的评估。因此，这将使其能够应用于沉积物管理程序，这是dioRAMA项目的主要目标之一。

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  • 来源
    《Journal of soil & sediments》 |2013年第4期|770-774|共5页
  • 作者

    Kathrin Eichbaum; Markus Brinkmann; Sebastian Buchinger; Markus Hecker; Magnus Engwall; Bert van Bavel; Georg Reifferscheid; Henner Hollert;

  • 作者单位

    Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany;

    Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany;

    German Federal Institute of Hydrology (BfC), Am Mainzer Tor 1, 56068 Koblenz, Germany;

    Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon SK S7N 5B3, Canada,School of the Environment and Sustainability, University of Saskatchewan, 44 Campus Drive, Saskatoon SK S7N 5B3, Canada;

    Man-Technology-Environment Research Centre (MTM), Department of Natural Science, University of Orebro, 70182 Orebro, Sweden;

    Man-Technology-Environment Research Centre (MTM), Department of Natural Science, University of Orebro, 70182 Orebro, Sweden;

    German Federal Institute of Hydrology (BfC), Am Mainzer Tor 1, 56068 Koblenz, Germany;

    Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany;

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    biomarker of effect and exposure; dioxin-like activity; rutilus rutilus;

    机译：作用和暴露的生物标志物;二恶英样活性;util鱼;

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