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Autocatalytic sets in E. coli metabolism

机译:大肠杆菌代谢中的自催化作用

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Background A central unsolved problem in early evolution concerns self-organization towards higher complexity in chemical reaction networks. In theory, autocatalytic sets have useful properties to help model such transitions. Autocatalytic sets are chemical reaction systems in which molecules belonging to the set catalyze the synthesis of other members of the set. Given an external supply of starting molecules – the food set – and the conditions that (i) all reactions are catalyzed by at least one molecule, and (ii) each molecule can be constructed from the food set by a sequence of reactions, the system becomes a reflexively autocatalytic food-generated network (RAF set). Autocatalytic networks and RAFs have been studied extensively as mathematical models for understanding the properties and parameters that influence self-organizational tendencies. However, despite their appeal, the relevance of RAFs for real biochemical networks that exist in nature has, so far, remained virtually unexplored.
机译:背景技术在早期发展中尚未解决的中心问题涉及化学反应网络中向更高复杂性的自组织。从理论上讲,自催化集具有有用的特性来帮助对这种转变进行建模。自催化组是化学反应系统,其中属于该组的分子催化该组其他成员的合成。给定外部供应的起始分子(食物组),以及以下条件:(i)所有反应均由至少一个分子催化,并且(ii)每个分子都可以通过一系列反应从食物组中构建,该系统成为反射性自催化食物生成网络(RAF集)。自催化网络和RAF作为数学模型已被广泛研究,以了解影响自组织趋势的特性和参数。然而,尽管它们具有吸引力,但到目前为止,RAF与自然界中存在的真实生化网络的相关性尚未得到充分探索。

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