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首页> 外文期刊>繊維学会誌 >Impregnation of Tranilast to the Poly(lactic acid) Fiber with Supercritical Carbon Dioxide and the Release Behavior of Tranilast
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Impregnation of Tranilast to the Poly(lactic acid) Fiber with Supercritical Carbon Dioxide and the Release Behavior of Tranilast

机译：超临界二氧化碳将曲尼司特浸渍到聚乳酸纤维中和曲尼司特的释放行为

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摘要

The impregnation of hydrophobia drug,tranilast,to the poly(lactic acid) (PLA) fiber with supercritical carbon dioxide (scCO_2) and the release behavior of tranilast from the PLA fiber were studied.The adsorption behavior of tranilast to the PLA fiber was evaluated.Equilibrium adsorption of tranilast was obtained in 60 min.The amount of adsorbed tranilast in equilibrium was 0.3-0.5% on the weight of fiber.The apparent diffusion coefficient was estimated from the apparent adsorption curve.The order of this value was 10~(-12)m~2/s.The tensile strength and modulus of the PLA fiber treated with scCO_2/EtOH decreased,as compared to the untreated fiber.By the scanning microspectrophotometric measurements,it was confirmed that tranilast was distributed uniformly in the PLA fiber.It was revealed that the tranilast was not crystallized in the PLA fiber.A fairly slow release of tranilast from the PLA fiber was observed in buffer solution.The amount of released tranilast after 60 days was about 20% of the total drug amount introduced into the body of a rat.
机译：研究了超疏水二氧化碳（scCO_2）对疏水性药物tranilast对聚乳酸（PLA）纤维的浸渍作用以及曲尼司特从PLA纤维的释放行为。评价了曲尼司特在PLA纤维上的吸附行为。在60分钟内获得曲尼司特的平衡吸附，曲尼司特在纤维重量上的平衡吸附量为0.3-0.5％，根据表观吸附曲线估算表观扩散系数，该值的阶次为10〜（ -12）m〜2 / s。scCO_2 / EtOH处理的PLA纤维的拉伸强度和模量与未处理的纤维相比有所降低。通过扫描分光光度法测定，曲尼司特在PLA纤维中分布均匀结果表明，曲尼司特在PLA纤维中未结晶，在缓冲溶液中观察到曲尼司特从PLA纤维中的释放相当缓慢，60天后曲尼司特的释放量约为20引入大鼠体内的药物总量的％。

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  • 来源
    《繊維学会誌》 |2005年第6期|p.159-165|共7页
  • 作者

    Kazuaki Sugiura; Satoshi Ogawa; Isao Tabata; Teruo Hori;

  • 作者单位

    Kyoto Municipal Industrial Research Institute,Textile Research Center,Kyoto 602-0898,Japan;

    Kyoto Municipal Industrial Research Institute,Textile Research Center,Kyoto 602-0898,Japan;

    Faculty of Engineering,Fukui University,Fukui 910-8507,Japan;

    Faculty of Engineering,Fukui University,Fukui 910-8507,Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学纤维工业;
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