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首页> 外文期刊>Journal of the American Water Resources Association >THE EFFECT OF ESTROGENS, RIVER WATER, AND TREATED WASTEWATER ON VITELLOGENIN INDUCTION OF JAPANESE MEDAKA
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THE EFFECT OF ESTROGENS, RIVER WATER, AND TREATED WASTEWATER ON VITELLOGENIN INDUCTION OF JAPANESE MEDAKA

机译：雌激素，河流水和处理过的废水对日本ME的卵黄素诱导的影响

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摘要

The objective of this study is to evaluate the effect of estrogens on fish endocrine disruption in river water and treated wastewater. Endogenous estrogen estrone (E1), 17β-estradiol (E2), river water, and treated wastewater were used for exposure tests on male Japanese medaka. Vitellogenin induction in male medaka was regarded as the endpoint of endocrine disruption. The effective concentrations of E1 and E2 on vitellogenin induction in medaka were evaluated by breeding medaka for 14 days in tanks with various concentrations of E1 or E2. Vitellogenin induction increased with elapse of time during exposure, with higher estrogen concentrations causing greater vitellogenin induction. According to the test results, the lowest observed effect concentrations (LOECs) of E1 and E2 were estimated to be 31.6 and 5.0 ng/1, respectively; and the E2 equivalent (EEQ) LOEC value of El was 5.2 ng-E2/1, derived by multiplying the relative potency of E1 by that of E2 as estimated in this study. In continuous exposure tests using river water or treated wastewater, the estrogenic activity, an index of total estrogenic potential measured by yeast screen assay and expressed as EEQ, varied widely during the exposure tests, and significant vitellogenin induction was observed after several days of high levels of estrogenic activity in water. Vitellogenin concentration tended to significantly increase if EEQ exceeded the level of 5 ng-E2/1. The threshold value was substantially the same as the results for E1 and E2 exposure tests of medaka. Consequently, EEQ over 5 ng-E2/1 was revealed to have the potential to cause endocrine disruption of male medaka. As estrogenic activity exceeding 5 ng-E2/1 was observed in some rivers in Japan, total estrogenic potential needs to be further decreased at wastewater treatment plants to prevent fish endocrine disruption.
机译：这项研究的目的是评估雌激素对河水和经过处理的废水中鱼类内分泌干扰的影响。内源雌激素雌酮（E1），17β-雌二醇（E2），河水和处理过的废水用于雄性日本med的暴露测试。男性青med中的卵黄蛋白原诱导被认为是内分泌破坏的终点。通过在具有不同浓度的E1或E2的水箱中繁殖medaka达14天，评估medaka中E1和E2诱导卵黄蛋白原有效浓度。卵黄蛋白原的诱导随暴露时间的流逝而增加，较高的雌激素浓度导致卵黄蛋白原的诱导更大。根据测试结果，E1和E2的最低观察到的效应浓度（LOEC）估计分别为31.6和5.0 ng / 1。通过将E1的相对效价乘以E2的相对效价得出，E1的E2当量（EEQ）LOEC值为5.2 ng-E2 / 1。在使用河水或处理后的废水进行的连续暴露测试中，雌激素活性（通过酵母筛选测定测得的总雌激素潜能指数并表示为EEQ）在暴露测试中变化很大，并且在高水平几天后观察到明显的卵黄蛋白原诱导在水中的雌激素活性。如果EEQ超过5 ng-E2 / 1，则卵黄蛋白原浓度倾向于显着增加。该阈值与高的E1和E2暴露测试的结果基本相同。因此，发现超过5 ng-E2 / 1的EEQ有可能引起雄性青的内分泌干扰。由于在日本一些河流中观察到雌激素活性超过5 ng-E2 / 1，因此在污水处理厂需要进一步降低总雌激素潜力，以防止鱼类内分泌受到干扰。

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    Kiyoaki Kitamura; Kiyoshi Miyajima; Tadashi Higashitani; Norihide Nakada; Koya Komori; Yutaka Suzuki;

  • 作者单位

    Water Quality Team, Water Environment Research Group, Public Works Research Institute, 1-6 Minamihara, Tsukuba, Ibaraki, Japan;

    Water Quality Team, Water Environment Research Group, Public Works Research Institute, 1-6 Minamihara, Tsukuba, Ibaraki, Japan;

    Water Quality Team, Water Environment Research Group, Public Works Research Institute, 1-6 Minamihara, Tsukuba, Ibaraki, Japan;

    Water Quality Team, Water Environment Research Group, Public Works Research Institute, 1-6 Minamihara, Tsukuba, Ibaraki, Japan Research Center for Environmental Quality Management, Kyoto University, 1-2 Yumihama, Otsu, Shiga, Japan;

    Water Quality Team, Water Environment Research Group, Public Works Research Institute, 1-6 Minamihara, Tsukuba, Ibaraki, Japan;

    Water Quality Team, Water Environment Research Group, Public Works Research Institute, 1-6 Minamihara, Tsukuba, Ibaraki, Japan;

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  • 正文语种 eng
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  • 关键词

    fish; ecotoxicology; endocrine disruption; estrogens; rivers; wastewater treatment plants;

    机译：鱼;生态毒理学内分泌干​​扰雌激素河流废水处理厂;

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