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首页> 外文期刊>Journal of Toxicology and Environmental Health, Part A: Current Issues >Contaminated Soils (III): In Vitro Dermal Absorption of Ethylene Glycol and Nonylphenol in Human Skin
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Contaminated Soils (III): In Vitro Dermal Absorption of Ethylene Glycol and Nonylphenol in Human Skin

机译：受污染的土壤（III）：人体皮肤中乙二醇和壬基酚的体外皮肤吸收

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摘要

Dermal absorption of contaminants from soils at federal contaminated sites in Canada was investigated using one hydrophile, 14C-ethylene glycol (EG), and one lipophile, 14C-nonylphenol (NP). In vitro dermal absorption of EG and NP was examined in dermatomed (0.4-0.5 mm) human skin using Bronaugh Teflon flow-through cells with Hanks HEPES buffered (pH 7.4) receiver solution with 4% bovine serum albumin (BSA). Tests were conducted under occlusive conditions with and without a commercial gardening soil spiked with EG or NP applied to skin at a soil load of 5 mg/cm2. With percent absorption in skin depot included, a total of 9.9 ± 6.28% ( n = 6) and 34.8 ± 8.47% ( n = 6) absorption of EG with and without soil, respectively, and 20.6 ± 5.56% ( n = 7) and 41.1 ± 6.46% ( n = 7) of NP, with and without soil, respectively, were obtained. For tests without soil a reverse pattern was observed with significantly lower percent absorption into the receiver than depot with the lipophile NP, but significantly higher percent absorption in receiver versus depot for the hydrophile EG. This pattern was different in tests with soil, and caution needs to be exercised when extrapolating data from in vitro tests conducted without soil in human health risk assessments at contaminated sites.
机译：使用一种亲水物 14 C-乙二醇（EG）和一种亲脂性物质 14 C-壬基苯酚（ NP）。使用带有Hanks HEPES缓冲液（pH 7.4）和4％牛血清白蛋白（BSA）的Hanks HEPES缓冲液（Bronaugh Teflon）流通池，在经皮切开（0.4-0.5 mm）的人皮肤中检查了EG和NP的体外真皮吸收。在闭塞条件下进行试验，在有或没有商业园艺土壤的情况下，在土壤负荷为5 mg / cm 2 的条件下向皮肤上掺入EG或NP。包括皮肤储库中的吸收百分比，总共有9.9±6.28％（n = 6）和34.8±8.47％（n = 6）的EG在有和没有土壤的情况下的吸收率分别为20.6±5.56％（n = 7）和41.1±6.46％（n = 7）的有和没有土壤的NP，分别获得。对于没有土壤的测试，观察到相反的模式，与亲油性NP相比，接收器中的吸收百分比显着低于亲油NP的仓库，但接收器中的吸收百分比高于亲油EG。在用土壤进行的测试中，这种模式有所不同，在从受污染地点进行的人类健康风险评估中推断出没有土壤进行的体外测试的数据时，应谨慎行事。

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