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首页> 外文会议>Symposium on environmental toxicology and risk assessment >Predicting dermal absorption from contact with chemically contaminated soils
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Predicting dermal absorption from contact with chemically contaminated soils

机译：预测与化学污染的土壤接触的皮肤吸收

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Dermal absorption from contaminated soils is poorly understood and more experimental study is needed. To guide selection of experimental variables for testing and to facilitate interpretation of resulting data, we have developed mathematical models describing dermal absorption of organic chemicals (1.59<=log_(10)K_(o/w) <=5.53 and MW<=700) from contaminated soils (with about 0.2percent or more organic carbon and with clay fractions which are less than 60 times the weight fraction of organic carbon). Assumptions about the kinetics of soil desorption relative to dermal absorption must be included in these models, although little quantitative information is presently available. Consequently, the models presented here represent two extreme situations in which either the dermal barrier, or the soil controls the rate of dermal absorption. For estimating the relative effect of changing exposure conditions (e.g., changes in soil loading, contamination levels, chemical, etc.), the predictions from both models are generally consistent with experimental results. However, the models assuming fast soil release kinetics perict more absorption than was observed experimentally for lindane and 2,4-D. This suggests that soil release kinetics may limit the amount of dermal absorption in at least some situations.
机译：受污染的土壤的真皮吸收很差，并且需要更实验的研究。要指导选择实验变量进行测试和促进对结果的解释，我们开发了描述了描述有机化学品的真皮吸收的数学模型（1.59 <= log_（10）K_（O / W）<= 5.53和MW <= 700）来自受污染的土壤（约0.2％或更多的有机碳以及粘土馏分小于有机碳的重量分数的60倍）。关于土壤解吸动力学相对于皮肤吸收的假设必须包括在这些模型中，尽管目前可以获得很少的定量信息。因此，这里呈现的模型代表了真皮屏障或土壤控制皮肤吸收速率的两个极端情况。为了估计改变暴露条件的相对效果（例如，土壤载荷，污染水平，化学等）的相对效果，两种模型的预测通常与实验结果一致。然而，假设快速土壤释放动力学的模型涉及比林烷和2,4-D实验观察的吸收更多。这表明土壤释放动力学可能限制至少一些情况下的皮肤吸收量。

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