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首页> 外文期刊>Journal of visualization >Micro-vibrational erythrocyte sedimentation rate (ESR) for sensitive measurement of erythrocyte aggregation
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Micro-vibrational erythrocyte sedimentation rate (ESR) for sensitive measurement of erythrocyte aggregation

机译：微振性红细胞沉降率（ESR），用于敏感测量红细胞聚集

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摘要

The erythrocyte sedimentation rate (ESR) can act as a useful index of nonspecific disease activity in the diagnosis of inflammatory conditions. However, there are several drawbacks, including long time measurement. To promote ESR tendency, a micro-vibrational erythrocyte sedimentation rate (MV-ESR) was proposed. By controlling the profile of injecting flow rate into blood sample, air between the syringe pump and bottom of blood column was compressed and released. Micro-vibration (MV) is simple reciprocating flow including motion in both positive and negative directions in a line. It is determined as the edge of the interface between top of blood column and air is pinned under the pressure wave. From that, shear rate generated by determined MV is from 0 to 10~(-2) (s~(-1)) in this study. Extremely low shear conditions may enhance the probability of erythrocyte aggregation formation. During measurement, a meniscus of separated plasma and sedimented erythrocytes was recorded using a camera. For validation of the proposed MV-ESR method, the effects of hematocrit as well as the frequency and amplitude of flow in the sedimentation tube were investigated. To quantify the enhancement of MV-ESR, the area of relative gradient (A_(RG)) based on a relative gradient of 1 was used. When MV with a maximum flow rate of 1 mL/min and a period of 100 ms was produced until 15 min, MV-ESR exhibited the best performance. Then, the proposed technique was used to diagnose the ESR difference between a normal and periodontitis patient. The characteristic time (λ_(ESR)), indicating the degree completion of the erythrocyte sedimentation, of the periodontitis patients was lower than that of the control. Based on the experimental demonstrations, λ_(ESR) of the MV-ESR method has significant potential in the diagnosis of inflammatory conditions and prognosis of non-inflammatory conditions.
机译：红细胞沉降率（ESR）可以作为炎症条件诊断中的非特异性疾病活动的有用指标。但是，存在几个缺点，包括长时间测量。为了促进ESR趋势，提出了微振动红细胞沉降率（MV-ESR）。通过控制将流量注入血液样品的轮廓，压缩并释放注射器泵和血液底部之间的空气。微振动（MV）是简单的往复流，包括在线中的正面和负方向的运动。确定为血柱顶部之间的界面的边缘，空气在压力波下固定。从该研究中，通过确定的MV产生的剪切速率为0至10〜（-2）（S〜（-1））。极低的剪切条件可以增强红细胞聚集形成的概率。在测量期间，使用相机记录分离的血浆和沉淀的红细胞的半月斑。为了验证所提出的MV-ESR方法，研究了血细胞比容的影响以及沉降管中的流动的频率和幅度。为了量化MV-ESR的增强，使用基于1的相对梯度的相对梯度（A_（RG））的面积。当MV具有1ml / min的最大流速和100 ms的时间，MV-ESR表现出最佳性能。然后，所提出的技术用于诊断正常和牙周炎患者之间的ESR差异。表明红细胞沉降的程度完成的特征时间（λ_（ESR））低于对照的程度。基于实验演示，MV-ESR方法的λ_（ESR）具有巨大潜力在诊断炎性病症和非炎症病症的预后。

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