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首页> 外文期刊>Key Engineering Materials >Antibiotic-containing polylactide-co-glycolide and porous β-tricalcium phosphate composite for treating osteomyelitis
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Antibiotic-containing polylactide-co-glycolide and porous β-tricalcium phosphate composite for treating osteomyelitis

机译：含抗生素的聚丙交酯-乙交酯和多孔β-磷酸三钙复合材料治疗骨髓炎

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摘要

A composite of co-polymer of lactic and glycolic acids (PLGA) loaded with gatifloxacine (GFLX), an antibiotics, and a β-tricalcium phosphate (βTCP) porous ceramic body was prepared by a solvent-free process in which no toxic solvent was used. The GFLX-loaded PLGA released GFLX for 8 weeks in Hanks' balanced solution. The inhibitory zone diameter (26.25 ± 0.95 mm) for GFLX-containing PLGA disk against S. milleri was significantly larger than 18 mm, and comparable to that (24.88 ± 1.6 mm) for the KB paper disk containing 5 fig of GFLX/disk. This means that the GFLX-containing PLGA has the clinical efficacy. The molten PLGA containing GFLX was successfully loaded in the pores and on the surface of the porous PTCP ceramic at 120℃ at a reduced pressure of 0.02 MPa. The composite of GFLX-loaded porous PTCP ceramic would be promising for treating osteomyelitis.
机译：乳酸和乙醇酸共聚物（PLGA）负载加替沙星（GFLX），抗生素和β-磷酸三钙（βTCP）多孔陶瓷体的复合材料是通过无溶剂工艺制备的，其中没有有毒溶剂用过的。装有GFLX的PLGA在汉克斯的平衡解决方案中发布了8周的GFLX。含GFLX的PLGA圆盘对粟米链霉菌的抑制区直径（26.25±0.95 mm）显着大于18 mm，与包含5个无花果的GFLX /圆盘的KB纸盘的抑制区直径（24.88±1.6 mm）相当。这意味着含GFLX的PLGA具有临床功效。将含有GFLX的PLGA熔融液在0.02 MPa的减压下成功地在120℃的孔隙和多孔PTCP陶瓷的表面加载。载有GFLX的多孔PTCP陶瓷的复合材料有望用于治疗骨髓炎。

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