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首页> 外文期刊>Key Engineering Materials >Effect of Different Hydroxyapatite Particles on Malignant Melanoma Cell Behavior
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Effect of Different Hydroxyapatite Particles on Malignant Melanoma Cell Behavior

机译：不同羟基磷灰石颗粒对恶性黑色素瘤细胞行为的影响

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摘要

The effect of different hydroxyapatite particles on malignant melanoma cell was evaluated in vitro. Two kinds of short-rode hydroxyapatite particles, which range from 0.4 to 1 um and 0.5 to 1.5 um, were co-cultured with human's malignant melanoma (MM) cell line A375 for 24, 48, and 72 h. Both of these HA particles showed the same cell proliferation rate as blank control, and there was no statistically significant correlation of matrix metalloproteinases-2 (MMP-2) expression to the HA particle size. SEM images showed that the membrane of tumor cell, which co-cultured with HA particles, was shrunk. The cell superficial sentus was reduced and small size particle' effect was more obvious. Since immunohistochemistry and SEM data are qualitative technique, further precise methods might bring more information about the effect of HA particles on tumor behaviors. But this study can provide the bio-security test of micrometer HA particles in transplantation after tumor excision.
机译：体外评估了不同羟基磷灰石颗粒对恶性黑色素瘤细胞的作用。分别将0.4至1 um和0.5至1.5 um的两种短粗羟基磷灰石颗粒与人恶性黑色素瘤（MM）细胞系A375共同培养24、48和72小时。这两个HA颗粒均显示出与空白对照相同的细胞增殖速率，并且基质金属蛋白酶2（MMP-2）表达与HA颗粒大小在统计学上无显着相关性。 SEM图像显示与HA颗粒共培养的肿瘤细胞膜收缩。细胞浅表感觉减少，小颗粒效应更明显。由于免疫组化和SEM数据是定性技术，因此进一步的精确方法可能会带来有关HA颗粒对肿瘤行为影响的更多信息。但是这项研究可以为肿瘤切除后的移植中的微米级HA颗粒提供生物安全性测试。

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