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Site Dependence of Bone Formation Induced by rhBMP-2: Comparing Rat Parietal Bone and Heterotopic Back Region

机译:rhBMP-2诱导的骨形成的位点依赖性:比较大鼠顶骨和异位背部区域

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摘要

The purpose of this study was to compare the rate of bone formation and progression induced by Rh-BMP-2/atelocollagen complex between the periosteal and dermis regions in rats. In both cases, mature bone formation was preceded by mesenchymal cell proliferation and immature bone formation. In the periosteal region, bone formation was rapid: tissues were almost fully occupied with bone after 6 weeks of implantation, whereas in the dermis region bone tissue was only 80/100 occupied even after 24 weeks. Vascularization occurred at the cavities of the implant and appeared to be necessary in the formation of immature bone.
机译:这项研究的目的是比较大鼠骨膜和真皮区域之间由Rh-BMP-2 /脂肪胶原复合物诱导的骨形成和进展速度。在这两种情况下,成熟的骨形成之前都是间充质细胞增殖和未成熟的骨形成。在骨膜区域,骨形成迅速:植入6周后组织几乎被骨完全占据,而在真皮区域,即使在24周后,骨组织也仅占80/100。血管化发生在植入物的腔中,并且似乎在未成熟骨的形成中是必需的。

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