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首页> 外文期刊>Kidney >Intact Parathyroid Hormone in Egyptian Type 2 Diabetics with Chronic Hemodialysis: Impact of Glycaemic Control
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Intact Parathyroid Hormone in Egyptian Type 2 Diabetics with Chronic Hemodialysis: Impact of Glycaemic Control

机译：埃及2型糖尿病伴慢性血液透析患者的完整甲状旁腺激素：血糖控制的影响

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摘要

Osteodystrophy is one of the long-term haemodialysis complications. In diabetic end stage renal failure patients, it mainly occurs as an aplastic or low-turnover bone disease due to their low serum intact parathyroid hormone (iPTH) levels. The aim of the present study is to evaluate intact PTH level in in Egyptian type 2 diabetics with chronic hemodialysis and its relation to glycaemic control .patients. 140 Egyptian patients, their mean age was 60.4 ± 10.6 years were evaluated. They were maintained on regular hemodialysis (HD); 3 times/week, and the patients were divided into two groups according to primary kidney disease, diabetic (98 patients) and non-diabetic (42 patients) groups. Diabetic group was furtherly subdivided according to glycated hemoglobin to controlled (32 patients) and non-controlled diabetics (66 patients). Intact parathyroid hormone (iPTH), glycated hemoglobin (HbA1c), serum bone specific alkaline phosphatase, Albumin, Glucose, calcium, phosphorus and magnesium were estimated. Urea reduction ratio (URR) was estimated to evaluate the hemodialysis adequacy. The diabetic group had significantly lower values of iPTH and serum magnesium than non-diabetic group (p < 0.03 and p < 0.001 respectively). The uncontrolled diabetics had significantly lower values of iPTH, serum magnesium and serum albumin (p < 0.002, p < 0.002& p < 0.03 respectively) than the controlled group. The serum HbA1c levels were strongly correlated with the serum iPTH levels (P < 0.003). intact PTH was lower in diabetic hemodialysis patients; also, glycaemic control was associated with higher PTH levels. Keywords Parathyroid hormone - haemodialysis - type 2 diabetes - glycaemic control
机译：骨营养不良是长期血液透析并发症之一。在糖尿病末期肾衰竭患者中，由于其血清完整的甲状旁腺激素（iPTH）水平低，它主要以再生障碍或低周转性骨病的形式发生。本研究的目的是评估埃及2型糖尿病慢性血液透析患者的完整PTH水平及其与血糖控制患者的关系。评估了140名埃及患者，他们的平均年龄为60.4±10.6岁。他们定期进行血液透析（HD）；每周3次，根据原发性肾脏疾病将患者分为糖尿病组（98例）和非糖尿病组（42例）。根据糖化血红蛋白将糖尿病组进一步细分为对照组（32例）和非对照糖尿病（66例）。估计完整的甲状旁腺激素（iPTH），糖化血红蛋白（HbA1c），血清骨特异性碱性磷酸酶，白蛋白，葡萄糖，钙，磷和镁。估计尿素减少率（URR）可评估血液透析的充分性。糖尿病组的iPTH和血清镁含量显着低于非糖尿病组（分别为p <0.03和p <0.001）。不受控制的糖尿病患者的iPTH，血清镁和血清白蛋白值显着低于对照组（分别为p <0.002，p <0.002和p​​ <0.03）。血清HbA1c水平与血清​​iPTH水平高度相关（P <0.003）。糖尿病血液透析患者的完整PTH较低；同样，血糖控制与较高的PTH水平相关。关键词甲状旁腺激素血液透析2型糖尿病血糖控制

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