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Great Lakes' contaminants reduce sperm production and fertilizing ability in mice

机译：大湖区的污染物减少了小鼠的精子产生和受精能力

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The long-term effects of Great Lakes' contaminants on male reproductive performance resulting from lactational and dietary exposure were investigated. Female C57BL/6 J mice (F-0) were mated with DBA/2 J male mice to produce B_6D_2-F_1 offspring. Dams (F-0) were fed one of three treatment diets during lactation. The three treatment diets were: (ⅰ) diet C, containing lab chow and fish oil; (ⅱ) diet I, containing 60% Iowa carp and 40% lab chow; and (ⅲ) diet G, containing 60% Great Lakes' carp and 40% lab chow. Diet C served as a lab-chow control treatment, while diet I served as a fish-diet control treatment. Diet G contained 2500μg of polychlorinated biphenyls (PCBs) and 300μg of l,l-dichloro-2,2-bis-[p-chlorophenyl]ethylene (4,4′-DDE) per kilogram of feed. The offspring (F-l) were continued on their respective maternal treatment diets from weaning until termination. Greater neonatal mortality and lesser body weights were observed in the F-l male mice on diet G. Lesser fecundity was observed in one-year-old F-l male mice on diet G following pairing with non-treated female mice. The sperm concentration of F-l male mice on diet G was less than 30% of that of mice on diets C and I. The in vitro fertilizing ability of the sperm decreased to 10% of that of mice on the two control diets. Sperm motility, velocity, linearity and amplitude of lateral head (ALH) displacement were also decreased in 15-month-old F-l male mice on diet G.
机译：研究了大湖区污染物对泌乳和饮食暴露引起的男性生殖性能的长期影响。将雌性C57BL / 6 J小鼠（F-0）与DBA / 2 J雄性小鼠交配，以产生B_6D_2-F_1后代。在哺乳期间，给大坝（F-0）喂食三种治疗饮食之一。三种治疗饮食是：（ⅰ）饮食C，其中包含实验室食物和鱼油； （ⅱ）饮食I，其中含有60％的爱荷华州鲤鱼和40％的实验猪； （G）饮食G，其中包含60％的大湖鲤鱼和40％的实验食物。饮食C用作实验室控制食物，而饮食I用作鱼类饮食控制食物。日粮G每公斤饲料含2500微克多氯联苯（PCB）和300微克1,1-二氯-2,2-双-[对氯苯基]乙烯（4,4'-DDE）。从断奶到终止，继续使用后代（F-1）进行各自的母体治疗。在饮食G下的F-1雄性小鼠中观察到更高的新生儿死亡率和体重减轻。与未治疗的雌性小鼠配对后，在饮食G下的一岁大F-1雄性小鼠中观察到了较少的繁殖力。饮食G的F-1雄性小鼠的精子浓度小于饮食C和I的小鼠的精子浓度。两种对照饮食的精子的体外受精能力降低至小鼠的10％。饮食G的15个月大的F-1雄性小鼠的精子运动力，速度，线性和侧头（ALH）位移的幅度也降低了。

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