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首页> 外文期刊>Lakes & Reservoirs >High-performance liquid chromatography-bioassay profiles of endocrine disrupters discharged from point and non-point pollution sources in Lake Biwa basin
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High-performance liquid chromatography-bioassay profiles of endocrine disrupters discharged from point and non-point pollution sources in Lake Biwa basin

机译：琵琶湖流域点和非点污染源排放的内分泌干扰物的高效液相色谱-生物分析

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Toxic pollution loading from both point and non-point sources in Lake Biwa should be further reduced. In order to tackle toxicity problems, it is necessary to analyse characteristics of toxic pollution. We have developed a new profiling technique to display toxic distributions of endocrine disrupters in complex mixtures of environmental samples, using high-performance liquid chromatography in combination with yeast bioassays. We have applied this technique to the major point and non-point pollution sources in the Lake Biwa basin, that is, to municipal sewage-treatment water (point) and road dust (non-point). The dominant oestrogenic chemical in sewage-treatment water was 17 β-estradiol. The extracts from screened road dust showed arylhydrocarbon-receptor binding activity (AhR-ligand activity), with much of this located in smaller particles of sifted dust. There were at least seven major AhR-ligand peaks in the road-dust sample.
机译：琵琶湖的点源和面源毒性污染负荷都应进一步减少。为了解决毒性问题，有必要分析毒性污染的特征。我们已经开发出一种新的分析技术，可以使用高效液相色谱法结合酵母生物测定法，在环境样品的复杂混合物中显示内分泌干扰物的毒性分布。我们已将此技术应用于琵琶湖流域的主要点和非点污染源，即市政污水处理水（点）和道路扬尘（非点）。污水处理水中的主要雌激素化学物质为17β-雌二醇。从经过筛选的道路灰尘中提取的提取物表现出芳烃-受体结合活性（AhR-配体活性），其中大部分位于较小的经过筛分的灰尘中。道路扬尘样品中至少有七个主要的AhR-配体峰。

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