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首页> 外文期刊>Lasers in Medical Science >In vivo confocal laser scanning microscopy of hypopigmented macules: a preliminary comparison of confocal images in vitiligo, nevus depigmentosus and postinflammatory hypopigmentation
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In vivo confocal laser scanning microscopy of hypopigmented macules: a preliminary comparison of confocal images in vitiligo, nevus depigmentosus and postinflammatory hypopigmentation

机译：色素沉着斑的体内共聚焦激光扫描显微镜：白癜风，痣，色素沉着和炎症后色素沉着的共聚焦图像的初步比较

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The use of confocal laser scanning microscopy (CLSM) may be an eligible alternative for confirmation of the diagnosis of hypopigmented macules. Our purpose was to evaluate CLSM features for non-invasive imaging of vitiligo, nevus depigmentosus and postinflammatory hypopigmentation in vivo. A total of 68 patients with a clinical diagnosis of the aforementioned diseases were included in this study. CLSM was performed on lesional and adjacent normal appearing skin for all patients. In the active and stable phases of vitiligo, CLSM demonstrated a complete loss of melanin in lesional skin in 14 of 25 patients (56.0%) and 16 of 20 patients (80.0%), respectively. In 11 of 25 (44.0%) patients, the amount of melanin in lesional skin decreased in the active phase of vitiligo, but it is noteworthy to know that the melanin was distributed homogeneously in the dermal papillary rings. In four of 20 patients (20.0%), the dermal papillary rings disappeared completely, but some refractile granules and dendrites could be seen in the stable phase of vitiligo, which may indicate the start of vitiligo repigmentation. Although, in 20 of 20 patients (100%) with nevus depigmentosus, the dermal papillary rings lost their integrity and the content of melanin decreased obviously, there must have been melanin in the dermal papillary rings during its development in all patients. Simultaneously, the melanin was distributed heterogeneously in the dermal papillary rings. The content of melanin and dermal papillary rings in postinflammatory hypopigmentation probably depend on the depth and site of the inflammation; moreover, melanophages were observed in postinflammatory hypopigmentation but did not exist in vitiligo and nevus depigmentosus. In addition, the content of melanin and dermal papillary rings in adjacent normal appearing skin showed changes in the active phase of vitiligo but showed no changes in any of the patients in the stable phases of vitiligo, nevus depigmentosus and postinflammatory hypopigmentation. Differences based on CLSM in the aforementioned diseases were the content of melanin and its distribution pattern. CLSM may be useful to discriminate vitiligo, postinflammatory hypopigmentation and nevus depigmentosus in a non-invasive fashion.
机译：共聚焦激光扫描显微镜（CLSM）的使用可能是确认色素不足斑的诊断的合格选择。我们的目的是评估CLSM在体内对白癜风，痣样色素沉着和炎症后色素沉着不足的非侵入性成像的功能。本研究共纳入68例临床诊断为上述疾病的患者。对所有患者，均在病变和邻近正常出现的皮肤上进行CLSM。在白癜风的活跃期和稳定期，CLSM分别显示25例患者中的14例（56.0％）和20例患者16例（80.0％）的病变皮肤黑色素完全丧失。在25名患者中的11名（44.0％）中，病变皮肤中黑色素的含量在白癜风活跃期下降，但是值得注意的是黑色素均匀分布在真皮乳头环中。 20例患者中有4例（20.0％）的真皮乳头环完全消失，但在白癜风稳定期可以看到一些可折回的颗粒和树突，这可能表明白癜风的治疗已开始。尽管在20名（100％）色素沉着痣患者中，真皮乳头环丧失了完整性，黑色素的含量明显下降，但在所有患者的发展过程中，真皮乳头环中一定存在黑色素。同时，黑色素在真皮乳头环中异质分布。炎症后色素沉着不足时黑色素和真皮乳头状环的含量可能取决于炎症的深度和部位。此外，在炎症后色素沉着中观察到黑素噬菌体，但在白癜风和副色素痣中不存在。此外，在正常出现的邻近皮肤中黑色素和真皮乳头环的含量显示白癜风的活跃期发生了变化，但在白癜风，痣样色素沉着症和炎症后色素沉着不足的稳定期中，任何患者均未见变化。在上述疾病中，基于CLSM的差异在于黑色素的含量及其分布方式。 CLSM可用于以非侵入性方式区分白癜风，炎症后色素沉着和痣样色素沉着。

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