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首页> 外文期刊>Lasers in Medical Science >Low-level laser therapy (670 nm) on viability of random skin flap in rats
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Low-level laser therapy (670 nm) on viability of random skin flap in rats

机译：低水平激光治疗（670 nm）对大鼠随机皮瓣存活的影响

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摘要

This study investigated the effects of 670 nm laser, at different fluences, on the viability of skin flap in rats. One hundred male animals were used. The animals were divided into control group; group treated with 3 J/cm2; group treated with 6 J/cm2; group treated with 12 J/cm2 and group treated with 24 J/cm2. The skin flap was made on the backs of all animals studied, with a plastic sheet interposed between the flap and the donor site. Laser irradiation was done immediately after the surgery and on days 1, 2, 3 and 4 after surgery. The percentage of necrosis of the flap was calculated at the 7th postoperative day. Additionally, a sample of each flap was collected to enable us to count the blood vessels. Treated animals showed a statistically significant smaller area of necrosis than did the control group. The necrosis in the treated groups was 41.82% (group 2), 36.51% (group 3), 29.45% (group 4) and 20.37% (group 5). We also demonstrated that laser irradiation at 670 nm, at all doses used, had a stimulatory effect on angiogenesis. Our study showed that the 670 nm laser was efficient to increase the viability of the skin flap, at all fluences used, with a tendency of reaching better results at higher doses.
机译：这项研究调查了670 nm激光在不同注量下对大鼠皮瓣活力的影响。使用了一百只雄性动物。将动物分为对照组。 3 J / cm 2 处理的组； 6 J / cm 2 处理的组；治疗组以12 J / cm 2 处理，治疗组以24 J / cm 2 处理。在所有研究动物的背上制作皮瓣，在皮瓣和供体部位之间插入一块塑料片。手术后立即以及手术后第1、2、3和4天进行激光照射。在术后第7天计算皮瓣坏死的百分比。另外，收集每个皮瓣的样本以使我们能够计数血管。与对照组相比，治疗动物的坏死面积在统计学上显着减小。治疗组的坏死率为41.82％（第2组），36.51％（第3组），29.45％（第4组）和20.37％（第5组）。我们还证明了在所有剂量下在670 nm处进行的激光辐照都对血管生成具有刺激作用。我们的研究表明，在使用了所有注量的情况下，670 nm激光都能有效提高皮瓣的活力，并且在高剂量下有达到更好效果的趋势。

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