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首页> 外文会议>Conference on optical interactions with tissue and cells >Effect of two laser photobiomodulation application protocols on the viability of random skin flap in rats
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Effect of two laser photobiomodulation application protocols on the viability of random skin flap in rats

机译：两种激光光生物调节应用方案对大鼠随机皮瓣存活的影响

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Objective: to identify the best low intensity laser photobiomodulation application site to increase the viability of the cutaneous flap in rats. Methods: 18 male rats (Rattus norvegicus: var. Albinus, Rodentia Mammalia) were randomly distributed into 3 groups (n = 6). Group Ⅰ (GⅠ) was submitted to simulated laser photobiomodulation, group Ⅱ (GⅡ) was submitted to the laser photobiomodulation at three points in the flap cranial base, and group Ⅲ (GⅢ) was submitted to laser photobiomodulation at twelve points distributed along the flap. All groups were irradiated with an Indium, Galium, Aluminum and Phosphorus diode laser (InGaAlP), 660 nm, with power of 50 mW, total energy of 12 J in continuous emission mode. The treatment started immediately after performing the cranial base random skin flap (dimension of 10×4 cm~2) and reapplied every 24 hours, with a total of 5 applications. The animals were euthanized after the evaluation of the percentage of necrosis area and the material was collected for histological analysis on the 7th postoperative day. Results: GⅡ animals presented a statistically significant decrease for the necrosis area when compared to the other groups, and a statistically significant increase in the quantification of collagen when compared to the control. We did not observe a statistical difference between the TGFβ and FGF expression in the different groups evaluated. Conclusion: the application of laser photobiomodulation at three points of the flap cranial base was more effective than at twelve points regarding the reduction of necrosis area.
机译：目的：确定最佳的低强度激光光生物调节应用部位，以增加大鼠皮瓣的生存能力。方法：将18只雄性大鼠（北att（Rattus norvegicus）：阿尔比努斯犬（Albinus），啮齿类动物哺乳动物）随机分为3组（n = 6）。 Ⅰ组（GⅠ）进行皮瓣模拟激光光生物调制，Ⅱ组（GⅡ）进行皮瓣颅底三个位置的激光光生物调制，Ⅲ组（GⅢ）进行皮瓣分布的十二个激光光生物调制。 。所有组均以660 nm的铟，镓，铝和磷二极管激光（InGaAlP）照射，功率为50 mW，在连续发射模式下的总能量为12J。进行颅底无规则皮瓣（尺寸为10×4 cm〜2）后立即开始治疗，每24小时重新应用一次，共进行5次应用。在评估坏死面积百分比后，对动物实施安乐死，并在术后第7天收集材料用于组织学分析。结果：与其他组相比，GⅡ动物的坏死面积明显减少，与对照组相比，胶原定量增加。我们在所评估的不同组中未观察到TGFβ和FGF表达之间的统计学差异。结论：在减少皮瓣坏死面积方面，在皮瓣颅底的三个部位应用激光生物调制比在十二个部位更有效。

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