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首页> 外文期刊>Lipids >Altered Lipid Response in Hamsters Fed cis-9,trans-11+trans-8,cis-10 Conjugated Linoleic Acid Mixture
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Altered Lipid Response in Hamsters Fed cis-9,trans-11+trans-8,cis-10 Conjugated Linoleic Acid Mixture

机译：仓鼠喂食cis-9，trans-11 + trans-8，cis-10共轭亚油酸混合物的脂质反应改变

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摘要

The objective of the present study was to compare the effects of cis-9,trans-11 + trans-8,cis-10 conjugated linoleic acid (CLA) mixture to those of cis-9,trans-11 + trans-10,cis-12 CLA mixture and linoleic acid (LA) on lipoprotein profile, hepatic lipids, body composition and digestibility of dietary fat in hamsters (n = 17) fed diets containing 2% of experimental fat (w/w) for 28 days. The cis-9,trans-11 + trans-10,cis-12 CLA mixture showed higher LDL cholesterol concentrations than LA and the cis-9,trans-11 + trans-8,cis-10 CLA mixture. The cis-9,trans-11 + trans-8,cis-10 CLA mixture induced similar plasma LDL cholesterol and hepatic lipid concentrations, and coefficient of digestibility as LA, indicating no effect of the trans-8,cis-10 CLA isomer on these lipid parameters. On the other hand, the cis-9,trans-11 + trans-8,cis-10 CLA mixture induced higher plasma VLDL cholesterol and triglycerides than LA and the cis-9,trans-11 + trans-10,cis-12 CLA mixture. The cis-9,trans-11 + trans-8,cis-10 CLA mixture also induced the highest plasma glucose concentrations compared with the two other groups, indicating an impairment of glycemic control. No differences in body composition were noted between the three groups. The present results thus show that the cis-9,trans-11 + trans-8,cis-10 CLA mixture can deteriorate plasma VLDL cholesterol and triglycerides in hamsters, possibly due to an increased flux of glucose.
机译：本研究的目的是比较cis-9，trans-11 + trans-8，cis-10共轭亚油酸（CLA）混合物与cis-9，trans-11 + trans-10，cis的影响-12 CLA混合物和亚油酸（LA）对饲喂含2％实验脂肪（w / w）的日粮28天的仓鼠（n = 17）中脂蛋白谱，肝脂质，身体成分和膳食脂肪消化率的影响。 cis-9，trans-11 + trans-10，cis-12 CLA混合物的LDL胆固醇浓度高于LA和cis-9，trans-11 + trans-8，cis-10 CLA混合物。顺式9，反式11 +反式8，顺式10 CLA混合物诱导的血浆LDL胆固醇和肝脂质浓度相似，消化率与LA相似，表明反式8，顺式10 CLA异构体对这些脂质参数。另一方面，与LA和cis-9，trans-11 + trans-10，cis-12 CLA相比，cis-9，trans-11 + trans-8，cis-10 CLA混合物诱导更高的血浆VLDL胆固醇和甘油三酸酯混合物。与其他两组相比，顺式9，反式11 +反式8，顺式10 CLA混合物还诱导了最高的血浆葡萄糖浓度，表明血糖控制受损。三组之间的身体组成没有差异。因此，本发明结果表明，顺式9，反式11 +反式8，顺式10 CLA混合物可以使仓鼠血浆VLDL胆固醇和甘油三酸酯劣化，这可能是由于葡萄糖通量增加所致。

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