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首页> 外文期刊>Marine biology >Imposex in marine gastropods may be caused by binding of organotins to retinoid X receptor
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Imposex in marine gastropods may be caused by binding of organotins to retinoid X receptor

机译：海洋腹足类动物的强加剂可能是由于有机锡与类维生素A X受体的结合引起的

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摘要

Organotin compounds have been widely used as antifouling paints for ships and fishing nets since the 1960s and have thus been released into marine environments. Aquatic invertebrates, particularly marine gastropods, are extremely sensitive to organotin compounds such as tributyltin (TBT) and triphenyltin (TPT) and undergo changes in sexual identity in response to exposure. This worldwide phenomenon is one of the worst consequences of pollution by man-made chemicals and has led to the ban of such compounds in antifouling paints in a number of countries, although organotin compounds still exist in the environment. So far, very low-concentrations of TBT or TPT have been shown to induce imposex (superimposition of male genitalia on female) in marine gastropods. Although the imposex induction mechanism has been controversial for many years, it was recently reported that TBT and TPT are potent and efficacious activators of retinoid X receptor (RXR), a member of the nuclear receptor superfamily. In this review, I discuss the involvement of RXR in the development of gastropod imposex.
机译：自1960年代以来，有机锡化合物已被广泛用作船舶和渔网的防污涂料，因此被释放到海洋环境中。水生无脊椎动物，尤其是海洋腹足类动物，对有机锡化合物（例如三丁基锡（TBT）和三苯基锡（TPT））极为敏感，并且会因暴露而发生性变化。尽管有机锡化合物仍存在于环境中，但这种世界范围的现象是人造化学物质污染最严重的后果之一，并导致许多国家在防污涂料中禁止使用此类化合物。迄今为止，已经证明非常低浓度的TBT或TPT会引起海洋腹足动物强加于人（男性生殖器叠加在女性身上）。尽管imposex诱导机制一直存在争议，但最近有报道称TBT和TPT是类视黄醇X受体（RXR）（核受体超家族成员）的有效激活剂。在这篇综述中，我讨论了RXR在腹足类动物胶乳的发展中的作用。

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  • 来源
    《Marine biology》 |2006年第1期|p.117-124|共8页
  • 作者

    Jun-ichi Nishikawa;

  • 作者单位

    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, 565-0871 Osaka, Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 环境生物学;
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