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首页> 外文期刊>Marine Environmental Research >Tributyltin exposure results in craniofacial cartilage defects in rockfish (Sebastiscus marmoratus) embryos
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Tributyltin exposure results in craniofacial cartilage defects in rockfish (Sebastiscus marmoratus) embryos

机译：三丁基锡暴露导致石鱼（Sebastiscus marmoratus）胚胎的颅面软骨缺损

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摘要

Tributyltin (TBT) is a ubiquitous marine environmental contaminant, which has been known to cause axial skeletal deformities in fish embryos. However, the effects of TBT on the craniofacial cartilage development of fishes remain unclear. The present study was designed to investigate the effects of waterborne TBT at environmental levels (0, 0.1, 1, and 10 ng L~(-1) as Sn) on craniofacial cartilage development in embryos of the rockfish (Sebastiscus marmoratus). Our study showed that TBT exposure induced craniofacial skeletal deformities, such as reduction of the craniofacial skeleton elements and a shorter lower jaw. The expressions of retinoic acid receptor a, sonic hedgehog, and proliferating cell nuclear antigen were depressed and the expressions of vitamin D receptor were increased in the rockfish embryos after TBT exposure. In addition, the activities of Ca~(2+)-ATPase were inhibited after TBT exposure. These results suggested that TBT might perturb the proliferation and differentiation of chondrocytes, and disturb calcium homeostasis, thus disorganizing craniofacial skeletal development.
机译：三丁基锡（TBT）是一种普遍存在的海洋环境污染物，已知会导致鱼胚中的轴向骨骼畸形。但是，TBT对鱼类颅面软骨发育的影响尚不清楚。本研究旨在研究环境水平（0、0.1、1和10 ng L〜（-1）作为Sn）中的水性TBT对岩鱼（Sebastiscus marmoratus）胚胎的颅面软骨发育的影响。我们的研究表明，TBT暴露会引起颅面骨骼畸形，例如颅面骨骼元素减少和下颌较短。暴露于TBT后，在石鱼胚胎中视黄酸受体α，声波刺猬和增殖细胞核抗原的表达降低，维生素D受体的表达增加。另外，TBT暴露后Ca〜（2 +）-ATPase活性被抑制。这些结果表明，TBT可能会扰乱软骨细胞的增殖和分化，并扰乱钙稳态，从而破坏颅面骨骼的发育。

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  • 来源
    《Marine Environmental Research》 |2012年第6期|p.6-11|共6页
  • 作者

    Jiliang Zhang; Zhenghong Zuo; Ping Sun; Hongwei Wang; Ang Yu; Chonggang Wang;

  • 作者单位

    College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, PR China;

    State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, PR China;

    College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, PR China;

    College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, PR China;

    State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, PR China;

    State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, PR China,Department of Biology, Xiamen University, 422 Siming South Road, Xiamen. Fujian 361005, PR China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    tributyltin; sebastiscus marmoratus; embryos; craniofacial cartilage; effects-fish; environmental toxicology;

    机译：三丁基锡鲈鱼胚胎颅面软骨;效果鱼环境毒理学;

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