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首页> 外文期刊>Marine Environmental Research >Pyrene exposure influences the craniofacial cartilage development of Sebastiscus marmoratus embryos
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Pyrene exposure influences the craniofacial cartilage development of Sebastiscus marmoratus embryos

机译：exposure的暴露影响马尔巴达斯（Sebastiscus marmoratus）胚胎的颅面软骨发育

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摘要

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants, which are known carcinogens and teratogens. However, the toxicity of PAHs during skeletal development and the mechanism involved are not completely clear. In the present study, rockfish (Sebastiscus marmoratus) embryos were exposed to pyrene (Pyr) for 7 days at 0.5, 5 and 50 nM which resulted in craniofacial skeleton deformities. Pyr exposure for 6 days reduced the expression of PCNA, Col2a1 and Sox9 in the craniofacial skeleton revealed using in situ hybridization. These results suggest that Pyr exposure impairs skeleton development via disrupting the proliferation of the chondrocytes. At the same time, Pyr exposure reduced the expression of lox1 and inhibited the activity of lysyl oxidase, which is the key enzyme controlling the collagen cross-linking, and which might therefore have been one of the reasons for the deformative Meckel's cartilage (lower jaw).
机译：多环芳烃（PAHs）是普遍存在的环境污染物，被称为致癌物和致畸物。但是，PAHs在骨骼发育过程中的毒性及其机制尚不完全清楚。在本研究中，石鱼（Sebastiscus marmoratus）胚胎在0.5、5和50 nM下暴露于pyr（Pyr）7天，导致颅面骨骼畸形。暴露6天的Pyr降低了使用原位杂交揭示的颅面骨架中PCNA，Col2a1和Sox9的表达。这些结果表明，Pyr暴露通过破坏软骨细胞的增殖而损害骨骼发育。同时，暴露于Pyr会降低lox1的表达并抑制赖氨酰氧化酶的活性，而赖氨酰氧化酶是控制胶原交联的关键酶，因此可能是变形Meckel软骨（下颌骨）的原因之一。 ）。

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  • 来源
    《Marine Environmental Research》 |2012年第6期|p.30-34|共5页
  • 作者

    Xiao Shi; Chengyong He; Zhenghong Zuo; Ruixia Li; Donglei Chen; Rong Chen; Chonggang Wang;

  • 作者单位

    Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, School of Life Sciences, Xiamen University, Xiamen, China;

    Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, School of Life Sciences, Xiamen University, Xiamen, China;

    Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, School of Life Sciences, Xiamen University, Xiamen, China;

    Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, School of Life Sciences, Xiamen University, Xiamen, China;

    Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, School of Life Sciences, Xiamen University, Xiamen, China;

    State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China;

    Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, School of Life Sciences, Xiamen University, Xiamen, China,State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China,School of Life Sciences, Xiamen University, 422 Siming South Road, Xiamen, Fujian 361005, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    PAHs; pyrene; developmental abnormality; fish; ecotoxicology;

    机译：多环芳烃;发育异常;鱼;生态毒理学;

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