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首页> 外文期刊>Materials Letters >Layer-by-layer assembly of 3D alginate-chitosan-gelatin composite scaffold incorporating bacterial cellulose nanocrystals for bone tissue engineering
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Layer-by-layer assembly of 3D alginate-chitosan-gelatin composite scaffold incorporating bacterial cellulose nanocrystals for bone tissue engineering

机译：包含细菌纤维素纳米晶体的3D海藻酸盐-壳聚糖-明胶复合支架的逐层组装，用于骨组织工程

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摘要

Alginate hydrogel undergoes the poor and unstable mechanical strength, and the lack of cell recognition sites for bone tissue engineering. For this reason, we attempted to fabricate alginate/bacterial cellulose nanocrystals-chitosan-gelatin (Alg/BCNs-CS-GT) composite scaffold by the combined method involving the incorporation of bacterial cellulose nanocrystals (BCNs) in alginate matrix, internal gelation by hydroxyapatite-D-glucono-delta-lactone (HAP-GDL) complex and layer-by-layer (LBL) electrostatic assembly of positively charged chitosan (CS) and negatively charged gelatin (GT). The characterization results revealed that Alg/BCNs-CS-GT composite scaffold exhibited good 3D architecture with well-defined porous structure, improved compressive strength and regulated biodegradation. In particular, the excellent bio-compatibility and the reinforcing effect of BCNs, and the outer GT chains containing repetitive motifs of arginine-glycine-aspartic (RGD) sequences favored the attachment, proliferation and differentiation of osteoblastic MC3T3-E1 cells. (C) 2017 Elsevier B.V. All rights reserved.
机译：海藻酸盐水凝胶的机械强度差且不稳定，并且缺乏用于骨组织工程的细胞识别位点。由于这个原因，我们试图通过组合方法制造藻酸盐/细菌纤维素纳米晶体-壳聚糖-明胶（Alg / BCNs-CS-GT）复合支架，包括在藻酸盐基质中掺入细菌纤维素纳米晶体（BCNs），羟基磷灰石内部凝胶化-D-葡萄糖酸-δ-内酯（HAP-GDL）复合物和带正电的壳聚糖（CS）和带负电的明胶（GT）的逐层（LBL）静电组装。表征结果表明，Alg / BCNs-CS-GT复合支架表现出良好的3D结构，具有清晰的多孔结构，提高的抗压强度和受控的生物降解性。特别是BCNs的优异生物相容性和增强作用，以及含有精氨酸-甘氨酸-天冬氨酸（RGD）序列重复基序的外部GT链有利于成骨细胞MC3T3-E1细胞的附着，增殖和分化。 （C）2017 Elsevier B.V.保留所有权利。

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  • 来源
    《Materials Letters》 |2017年第15期|492-496|共5页
  • 作者

    Yan Huiqiong; Chen Xiuqiong; Feng Meixi; Shi Zaifeng; Zhang Dashuai; Lin Qiang;

  • 作者单位

    Hainan Normal Univ, Coll Chem & Chem Engn, Haikou 571100, Hainan, Peoples R China;

    Hainan Normal Univ, Coll Chem & Chem Engn, Haikou 571100, Hainan, Peoples R China;

    Hainan Normal Univ, Coll Chem & Chem Engn, Haikou 571100, Hainan, Peoples R China;

    Hainan Normal Univ, Coll Chem & Chem Engn, Haikou 571100, Hainan, Peoples R China;

    Hainan Normal Univ, Coll Chem & Chem Engn, Haikou 571100, Hainan, Peoples R China;

    Hainan Normal Univ, Coll Chem & Chem Engn, Haikou 571100, Hainan, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Alginate hydrogel; Layer-by-layer assembly; Polymeric composites; Biomaterials; Tissue engineering scaffold;

    机译：海藻酸盐水凝胶;分层组装;聚合物复合材料;生物材料;组织工程支架;

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