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首页> 外文期刊>Materials Science and Engineering >Atomic force microscopy and dark-toxicity pattern of unsymmetrical metallated porphyrins M(Ⅱ)P-type as theranostics agents
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Atomic force microscopy and dark-toxicity pattern of unsymmetrical metallated porphyrins M(Ⅱ)P-type as theranostics agents

机译：M（Ⅱ）P型不对称金属化卟啉作为治疗试剂的原子力显微镜及暗毒性模式

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摘要

Two unsymmetrical metalloporphyrins, of M(II)P-type, Cu(II)-5-[(3,4-methylenedioxy)phenyl]-10,15,20-tris-(4-carboxymethylphenyl) porphyrin and Zn(II)-5-[(3,4-methylenedioxy)phenyl]-10,15,20 tris-(4-carboxymethylphenyl) porphyrin have been investigated by means of Atomic Force Microscopy (AFM) and in vitro cytotoxicity measurements. AFM studies emphasized the highly self-similarity of the investigated compounds on the basis of mean fractal dimension values. A specific morphology, consisting in alternative hillocks and valleys which have tens of nanometers, that are suitable for cell adhesion was observed. Short term as well as long term dark toxicity tests were performed on Human U937 cell line and Human peripheral mononuclear cells isolated from venous blood of normal volunteers and cancer patients. It was found that both short and long term incubation of U937 cells with Cu(II)P19.2 and Zn(II)P19.2 doesn't distress cellular viability, sustaining the nontoxic outline of M(II)P-type series upon monocytic cell line.
机译：M（II）P型的两个不对称金属卟啉Cu（II）-5-[（3,4-亚甲二氧基）苯基] -10,15,20-三-（4-羧甲基苯基）卟啉和Zn（II）通过原子力显微镜（AFM）和体外细胞毒性测量研究了-5-[（3,4-亚甲二氧基）苯基] -10,15,20三-（4-羧甲基苯基）卟啉。原子力显微镜研究强调了基于平均分形维数值的被研究化合物的高度自相似性。观察到一种特定的形态，该形态由几十个纳米的丘陵和山谷组成，适于细胞粘附。对从正常志愿者和癌症患者的静脉血中分离的人U937细胞系和人外周血单个核细胞进行了短期和长期的暗毒性试验。已经发现，U937细胞与Cu（II）P19.2和Zn（II）P19.2的短期和长期孵育都不会损害细胞生存力，从而在维持M（II）P型系列无毒轮廓的同时单核细胞系。

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  • 来源
    《Materials Science and Engineering》 |2019年第6期|85-94|共10页
  • 作者

    Socoteanu Radu; Anastasescu Mihai; Boscencu Rica; Constantin Carolina; Neagu Monica;

  • 作者单位

    Romanian Acad, Ilie Murgulescu Inst Phys Chem, 202 Splaiul Independentei, Bucharest 060021, Romania;

    Romanian Acad, Ilie Murgulescu Inst Phys Chem, 202 Splaiul Independentei, Bucharest 060021, Romania;

    Carol Davila Univ Med & Pharm, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania;

    Victor Babes Natl Inst Pathol & Biomed Sci, 99-101 Splaiul Independentei, Bucharest 050096, Romania;

    Victor Babes Natl Inst Pathol & Biomed Sci, 99-101 Splaiul Independentei, Bucharest 050096, Romania|Colentina Univ Hosp, 19-21 Stefan cel Mare Bld, Bucharest 020125, Romania|Univ Bucharest, Fac Biol, 91-95 Splaiul Independentei, Bucharest 050095, Romania;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Porphyrins; AFM; Cell experiments; Dark toxicity; Theranostics;

    机译：卟啉;AFM;细胞实验;暗毒性;治疗学;

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