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Study of CRP immobilization on nanostructured silicon

机译：CRP固定在纳米结构硅上的研究

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摘要

C-reactive protein (CRP) is a phylogenetically highly conserved plasma protein, which is widely used as an indicator of inflammatory states due to rapid increase of its plasma concentration up to 1000 times compared to normal values. Detection of CRP levels in a rapid, simultaneous and multiplex format is therefore of great interest for diagnostics. Microarray technology could provide such a multiplex format of CRP levels detection. Different nanostructured porous silicon (PS) surfaces were obtained and used for the immobilization of CRP and anti-human CRP antibodies in order to achieve an optimum microarray assay. Comparative analysis of the attachment degree and preservation of the biomolecules activity on the silicon surfaces and functionalized glass slides is also described.
机译：C反应蛋白（CRP）是系统进化上高度保守的血浆蛋白，由于其血浆浓度与正常值相比迅速增加至1000倍，因此被广泛用作炎症状态的指标。因此，以快速，同步和多重格式检测CRP水平对于诊断非常重要。微阵列技术可以提供这种CRP水平检测的多重格式。获得了不同的纳米结构多孔硅（PS）表面，并将其用于CRP和抗人CRP抗体的固定化，以实现最佳的微阵列测定。还描述了在硅表面和功能化玻璃载片上的附着度和生物分子活性的保留程度的比较分析。

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  • 来源
    《Materials Science and Engineering》 |2010年第3期|p.67-72|共6页
  • 作者

    Monica Simion; Lavinia L. Ruta; Mihaela Matache; Irina Kleps; Mihaela Miu; Codruta C. Paraschivescu; Adina Bragaru; Teodora Ignat;

  • 作者单位

    National Institute for Research and Development in Microtechnologies (IMT - Bucharest), 32B Erou Iancu Nicolae Street, 72996 Bucharest, Romania;

    rnUniversity of Bucharest, Department of Chemistry, Division of Organic Chemistry, 90-92 Panduri Street, 050663 Bucharest Romania;

    rnUniversity of Bucharest, Department of Chemistry, Division of Organic Chemistry, 90-92 Panduri Street, 050663 Bucharest Romania;

    rnNational Institute for Research and Development in Microtechnologies (IMT - Bucharest), 32B Erou Iancu Nicolae Street, 72996 Bucharest, Romania;

    rnNational Institute for Research and Development in Microtechnologies (IMT - Bucharest), 32B Erou Iancu Nicolae Street, 72996 Bucharest, Romania;

    rnUniversity of Bucharest, Department of Chemistry, Division of Organic Chemistry, 90-92 Panduri Street, 050663 Bucharest Romania;

    rnNational Institute for Research and Development in Microtechnologies (IMT - Bucharest), 32B Erou Iancu Nicolae Street, 72996 Bucharest, Romania;

    rnNational Institute for Research and Development in Microtechnologies (IMT - Bucharest), 32B Erou Iancu Nicolae Street, 72996 Bucharest, Romania;

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  • 正文语种 eng
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  • 关键词

    protein microarray; porous silicon; C-reactive protein;

    机译：蛋白质芯片多孔硅C反应蛋白;

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