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首页> 外文期刊>Materials Science and Engineering >Development of composite nanoparticles composed of silica-coated nanorods and single nanometer-sized gold particles toward a novel X-ray contrast agent
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Development of composite nanoparticles composed of silica-coated nanorods and single nanometer-sized gold particles toward a novel X-ray contrast agent

机译：由二氧化硅涂覆纳米棒和单纳米尺寸的金颗粒组成的复合纳米粒子朝向新型X射线造影剂组成

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摘要

Gold (Au) is expected to function as a high contrast agent for X-ray computed tomography imaging as it has high X-ray absorptivity owing to a large atomic number compared to commercial materials such as barium and iodine. In addition, Au formation with a nanorod structure (AuNR) can be used for hyperthermia because of the enhancement of the photothermal reaction effect. The present work proposes a preparation method for core-shell nanoparticles composed of AuNR, SiO_2, and a single nanometer-sized Au (sAu), toward imaging and photothermal therapy. The AuNRs (lateral size: 12.6 nm; longitudinal size: 44.9 nm) were silica-coated using a sol-gel method with tetraethyl orthosilicate, which produced AuNR/SiO_2 nanoparticles with an average size of 86.9 nm. Thiol groups were introduced onto the AuNR/SiO_2 nanoparticle surface by using (3-mercaptopropyl) trimethoxysilane (AuNR/SiO_2-SH). The sAu nanoparticles (particle size: 2.6 nm) were produced by adding tetrakis (hydroxymethyl) phosphonium chloride as a reductant and HAuCl_4 (aq) to NaOH solution. A thiol-terminated PEG (PEG-SH) aqueous solution and sAu nanoparticle colloidal solution were added in turn to the AuNR/SiO_2-SH dispersed in EtOH (AuNR/SiO_2/sAu-PEG). The CT value of the AuNR/SiO_2/sAu-PEG particle solution was 702 HU. The CT values in tissues immediately increased after injection into mouse. Their blood retention times were 3-6 h, much longer than the few minutes of a commercial X-ray contrast agent (Iopamiron).
机译：金（Au）预计用作X射线计算断层摄影成像的高造影剂，因为由于与钡和碘的商业材料相比，由于大的原子序数具有高X射线吸收率。此外，由于光热反应效果的增强，具有纳米棒结构（AUNR）的Au形成可用于热疗。本作者提出了一种制备由AUNR，SiO_2和单纳米尺寸的Au（SAU）组成的核 - 壳纳米颗粒，朝向成像和光热疗法。 AUNRS（横向尺寸：12.6nm;纵向尺寸：44.9nm）使用具有四乙基硅酸盐的溶胶 - 凝胶法涂覆二氧化硅涂覆，其产生均匀尺寸为86.9nm的AUNR / SiO_2纳米颗粒。通过使用（3-巯基丙基）三甲氧基硅烷（AUNR / SiO_2-SH）将硫醇基团引入AUNR / SiO_2纳米颗粒表面上。通过将四（羟甲基）氯化铵作为还原剂和HauCl_4（水溶液）加入NaOH溶液，通过将SAU纳米粒子（粒径：2.6nm）制备。加入硫醇封端的PEG（PEG-SH）水溶液和SAU纳米粒子胶体溶液，依次进入分散在EtOH（AUNR / SIO_2 / SAU-PEG）中的AUNR / SIO_2-SH。 AUNR / SIO_2 / SAU-PEG颗粒溶液的CT值为702UU。在注射到小鼠后立即增加组织中的CT值。它们的血液保留时间为3-6小时，比商业X射线造影剂的几分钟长得多于几分钟（Iopamiron）。

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  • 来源
    《Materials Science and Engineering》 |2020年第12期|114716.1-114716.7|共7页
  • 作者

    Tomoya Inose; Takahiro Oikawa; Masayuki Tokunaga; Noriko Yamauchi; Kouichi Nakashima; Chihiro Kato; Keiichiro Hatoyama; Takashi Kamei; Kohsuke Gonda; Yoshio Kobayashi;

  • 作者单位

    Department of Medical Physics Graduate School of Medicine Tohoku University Sendai Japan;

    Department of Medical Physics Graduate School of Medicine Tohoku University Sendai Japan Department of Gastroenterological Surgery Graduate School of Medicine Tohoku University Sendai Japan;

    Department of Medical Physics Graduate School of Medicine Tohoku University Sendai Japan;

    Department of Materials Science and Engineering Graduate School of Science and Engineering Ibaraki University Hitachi Japan;

    Department of Materials Science and Engineering Graduate School of Science and Engineering Ibaraki University Hitachi Japan;

    Department of Medical Physics Graduate School of Medicine Tohoku University Sendai Japan;

    Department of Medical Physics Graduate School of Medicine Tohoku University Sendai Japan Department of Gastroenterological Surgery Graduate School of Medicine Tohoku University Sendai Japan;

    Department of Gastroenterological Surgery Graduate School of Medicine Tohoku University Sendai Japan;

    Department of Medical Physics Graduate School of Medicine Tohoku University Sendai Japan;

    Department of Materials Science and Engineering Graduate School of Science and Engineering Ibaraki University Hitachi Japan;

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  • 正文语种 eng
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  • 关键词

    Gold nanorod; Sol-gel; Silica-coating; X-ray imaging; Single nanometer-sized gold particle;

    机译：金纳罗德;溶胶 - 凝胶;二氧化硅涂层;X射线成像;单纳米尺寸的金颗粒;

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