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首页> 外文期刊>Materials science & engineering >Doxorubicin delivery via magnetic nanomicelles comprising from reduction- responsive poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-SS-PCL) and loaded with superparamagnetic iron oxide (SPIO) nanoparticles: Preparation, characterization and simulation
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Doxorubicin delivery via magnetic nanomicelles comprising from reduction- responsive poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-SS-PCL) and loaded with superparamagnetic iron oxide (SPIO) nanoparticles: Preparation, characterization and simulation

机译:阿霉素通过磁性纳米胶束传递,该胶束包含还原反应性聚乙二醇-b-聚ε-己内酯(PEG-SS-PCL),并负载超顺磁性氧化铁(SPIO)纳米颗粒:制备,表征和模拟

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摘要

Reduction-responsive biodegradable micelles were prepared by linking of poly(ethylene glycol) and poly(ε‑caprolactone) with disulfide bond (PEG-SS-PCL) for co-delivery of superparamagnetic iron oxide (SPIO) nanoparticles (NPs) and an anticancer agent, doxorubicin (DOX). This amphiphilic diblock copolymer shows redox-responsive properties, which is arising from disulfide bonds throughout the main chain. The ability of these copolymers for self-assembly with oleic acid modified SPIONs can help to organize nanomicelles in aqueous solution. Doxorubicin (DOX) was loaded in the magnetic nanomicelles with a loading of 32%. Coarse-Grained Molecular Dynamics (CG-MD) simulation approach was exploited to reassure the construction of self-assembled PEG-PCL micelles in presence of oleic acid and water solvent while the hydrophobic and hydrophilic ratios of each block copolymer were equally chosen and each oleic acid was connected to Fe3O4nanoparticles. Our results confirmed the stability, cytocompatibility, magnetic and redox-responsive properties for these self-assembled nanomicelles and revealed that the DOX-SPION-loaded reduction-sensitive nanomicelles could be used in drug targeting to the cancer cells.
机译:通过将聚乙二醇和聚ε-己内酯与二硫键(PEG-SS-PCL)连接以制备超顺磁性氧化铁(SPIO)纳米颗粒(NPs)和抗癌剂,制备出具有还原反应性的可降解胶束药剂,阿霉素(DOX)。该两亲性二嵌段共聚物显示出氧化还原响应性,这是由于整个主链上的二硫键所致。这些共聚物与油酸改性的SPIONs自组装的能力有助于在水溶液中组织纳米胶束。阿霉素(DOX)以32%的负载量负载在磁性纳米胶束中。利用粗粒分子动力学(CG-MD)模拟方法来确保在油酸和水溶剂存在下自组装PEG-PCL胶束的构建,同时均等选择每种嵌段共聚物的疏水性和亲水性比,并且每个油性酸连接到Fe3O4纳米颗粒上。我们的结果证实了这些自组装纳米胶束的稳定性,细胞相容性,磁性和氧化还原响应特性,并揭示了载有DOX-SPION的还原敏感性纳米胶束可用于靶向癌细胞的药物。

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