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Nano-radiogold-decorated composite bioparticles

机译：纳米放射性金修饰的复合生物颗粒

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Hybrid composite bioparticles modified with stable and radioactive gold nanoparticles were prepared via reduction of tetrachloroauric acid within Lactobacillus rhamnosus cells. The resulting biocomposite material was characterized using a number of physicochemical techniques, including microscopic, spectroscopic and thermal methods.The bacterial particles act as a type of template for gold deposition. Gold nanoparticles of approximately 3.7 nm diameter are formed and are uniformly distributed within the bacterial cell, including its hydrogel outer shell. For radioactive gold-198, the beta(-) radiation emitted from the biocomposite particles can be used for therapeutic purposes, as demonstrated in vitro in cancer cell cultures. The antitumor activity can be further enhanced by incorporation of doxorubicin, a cytostatic drug, within composite particles. The cell viability data indicate the considerable synergistic effect of beta(-) radiation and doxorubicin on breast cancer cells (MCF-7). The antitumor action of the biocomposite particles is very promising for new anticancer therapies.
机译：通过还原鼠李糖乳杆菌细胞内的四氯金酸，制备了用稳定的放射性金纳米颗粒修饰的杂化复合生物颗粒。所得的生物复合材料使用多种物理化学技术进行了表征，包括显微，光谱和热学方法。细菌颗粒充当金沉积模板的类型。形成直径约为3.7 nm的金纳米颗粒，并将其均匀分布在细菌细胞内，包括其水凝胶外壳。对于放射性金198，从生物复合材料颗粒发出的β（-）辐射可用于治疗目的，如体外在癌细胞培养中证明的那样。通过在复合颗粒中掺入阿霉素，一种细胞生长抑制药物，可以进一步增强抗肿瘤活性。细胞活力数据表明，β（-）辐射和阿霉素对乳腺癌细胞（MCF-7）具有明显的协同作用。生物复合颗粒的抗肿瘤作用对于新的抗癌治疗非常有前途。

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