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首页> 外文期刊>Materials science & engineering >A highly dispersed multi-walled carbon nanotubes and poly(methyl orange) based electrochemical sensor for the determination of an anti-malarial drug: Amodiaquine
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A highly dispersed multi-walled carbon nanotubes and poly(methyl orange) based electrochemical sensor for the determination of an anti-malarial drug: Amodiaquine

机译：一种高度分散的多壁碳纳米管和基于聚（甲基橙）的电化学传感器，用于测定抗疟药：阿莫二喹

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摘要

A glassy carbon electrode modified with electrochemically polymerized methyl orange (PMO) and multi-walled carbon nanotubes (MWCNT) was developed. The morphologies of the fabricating materials (PMO and MWCNT) were investigated by field-emission scanning electron microscopy (FE-SEM). The designed sensor was used for the sensitive determination of amodiaquine (AQ), an anti-malaria drug. AQ was developed as an alternative to chloroquine because of its activity against chloroquine-resistant Plasmodium falciparum (P. falcipanun) parasites. The modified electrode was employed to study the electrochemical oxidation of AQ using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Under optimal experimental conditions, DPV exhibited a linear response in the concentration range from 1.0 x 10(-7) to 3.5 x 10(-6) mol L-1 with a limit of detection (LOD) of 8.9 x 10(-8) mol L-1. Furthermore, the number of electrons and protons involved in the electrochemical study of AQ was also calculated and a plausible mechanism for the electro-oxidation of AQ was deduced. The developed sensor demonstrated analytical applicability as it was successfully employed to determine the drug AQ in pharmaceutical formulations and human urine samples.
机译：开发了一种用电化学聚合的甲基橙（PMO）和多壁碳纳米管（MWCNT）改性的玻璃碳电极。通过场发射扫描电子显微镜（FE-SEM）研究了制造材料（PMO和MWCNT）的形貌。设计的传感器用于灵敏测定抗疟药阿莫地喹（AQ）。由于AQ具有抗氯喹抗性恶性疟原虫（P. falcipanun）寄生虫的活性，因此被开发为氯喹的替代品。使用循环伏安法（CV）和差分脉冲伏安法（DPV）技术研究了修饰电极对AQ的电化学氧化作用。在最佳实验条件下，DPV在1.0 x 10（-7）到3.5 x 10（-6）mol L-1的浓度范围内表现出线性响应，检出限（LOD）为8.9 x 10（-8）摩尔L-1。此外，还计算了AQ电化学研究中涉及的电子和质子数，并推论出AQ电氧化的合理机理。研制成功的传感器具有分析适用性，因为它已成功用于确定药物制剂和人尿液样品中的药物AQ。

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