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首页> 外文期刊>Materials science & engineering >The summary of the most important cell-biomaterial interactions that need to be considered during in vitro biocompatibility testing of bone scaffolds for tissue engineering applications
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The summary of the most important cell-biomaterial interactions that need to be considered during in vitro biocompatibility testing of bone scaffolds for tissue engineering applications

机译：在组织工程应用的骨支架的体外生物相容性测试中需要考虑的最重要的细胞-生物材料相互作用的摘要

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摘要

Tissue engineered products (TEPs), which mean biomaterials containing either cells or growth factors or both cells and growth factors, may be used as an alternative to the autografts taken directly from the bone of the patients. Nevertheless, the use of TEPs needs much more understanding of biointeractions between biomaterials and eukaryotic cells. Despite the possibility of the use of in vitro cellular models for initial evaluation of the host response to the implanted biomaterial, it is observed that most researchers use cell cultures only for the evaluation of cytotoxicity and cell proliferation on the biomaterial surface, and then they proceed to animal models and in vivo testing of bone implants without fully utilizing the scientific potential of in vitro models. In this review, the most important biointeractions between eukaryotic cells and biomaterials were discussed, indicating molecular mechanisms of cell adhesion, proliferation, and biomaterial-induced activation of immune cells. The article also describes types of cellular models which are commonly used for biomaterial testing and highlights the possibilities and drawbacks of in vitro tests for biocompatibility evaluation of novel scaffolds. Finally, the review summarizes recent findings concerning the use of adult mesenchymal stem cells for TEP generation and compares the potential of bone marrow- and adipose tissue-derived stem cells in regenerative medicine applications.
机译：组织工程产品（TEP）是指既包含细胞又包含生长因子或同时包含细胞和生长因子的生物材料，可以用作直接取自患者骨骼的自体移植物的替代物。然而，TEP的使用需要更多地了解生物材料与真核细胞之间的生物相互作用。尽管可以使用体外细胞模型对宿主对植入的生物材料的反应进行初始评估，但据观察，大多数研究人员仅将细胞培养物用于评估生物材料表面的细胞毒性和细胞增殖，然后他们继续进行研究。动物模型和骨植入物的体内测试，而没有充分利用体外模型的科学潜力。在这篇综述中，讨论了真核细胞与生物材料之间最重要的生物相互作用，表明了细胞粘附，增殖和生物材料诱导的免疫细胞活化的分子机制。本文还介绍了通常用于生物材料测试的细胞模型的类型，并强调了体外测试用于新型支架生物相容性评估的可能性和缺点。最后，该综述总结了有关使用成人间充质干细胞进行TEP生成的最新发现，并比较了骨髓和脂肪组织来源的干细胞在再生医学应用中的潜力。

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