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首页> 外文期刊>Materials science & engineering >Hyaluronic acid/corn silk extract based injectable nanocomposite: A biomimetic antibacterial scaffold for bone tissue regeneration
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Hyaluronic acid/corn silk extract based injectable nanocomposite: A biomimetic antibacterial scaffold for bone tissue regeneration

机译：透明质酸/玉米丝提取物的可注射纳米复合材料：仿生抗菌支架，用于骨组织再生

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摘要

Injectable hydrogels have revealed the great potential for use as scaffolds in cartilage and bone tissue engineering. Here, thermosensitive and injectable hydrogels containing beta-tricakium phosphate, hyaluronic acid, and corn silk extract-nanosilver (CSE-Ag NPs) were synthesized for their potential use in bone tissue regeneration applications. Spherical nanoparticles of silver were biosynthesized through microwave-assisted green approach using CSE in organic solvent-free medium. Rheological experiments demonstrated that the thermosensitive hydrogels have gefification temperature (T-gel) close to body temperature. The samples containing Ag NPs showed antibacterial activity toward gram-positive (Bacillus Subtilis, Staphylococcus Aureus) and gram-negative (Pseudomonas Aeruginosa, Escherichia Colt) bacteria along without cytotoxicity after 24 h. Mesenchymal stem cells seeded in the nanocomposite exhibited high bone differentiation which indicate that thay could be a good candidate as a potential scaffold for bone tissue regeneration.
机译：可注射的水凝胶显示出在软骨和骨组织工程中用作支架的巨大潜力。在这里，合成了含有β-磷酸三钾，透明质酸和玉米丝提取物-纳米银（CSE-Ag NPs）的热敏性和可注射水凝胶，因为它们在骨组织再生应用中具有潜在用途。在无溶剂有机介质中，使用CSE通过微波辅助绿色方法生物合成了银的球形纳米颗粒。流变实验表明，热敏水凝胶的凝胶化温度（T-gel）接近于体温。含有Ag NPs的样品在24小时后对革兰氏阳性菌（枯草芽孢杆菌，金黄色葡萄球菌）和革兰氏阴性菌（铜绿假单胞菌，大肠杆菌）显示出抗菌活性，而没有细胞毒性。植入纳米复合材料的间充质干细胞显示出高的骨分化能力，这表明thay可以作为骨组织再生的潜在支架。

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