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首页> 外文期刊>Materials science & engineering >Tailoring the collagen film structural properties via direct laser crosslinking of star-shaped polylactide for robust scaffold formation
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Tailoring the collagen film structural properties via direct laser crosslinking of star-shaped polylactide for robust scaffold formation

机译：通过星形聚丙交酯的直接激光交联调整胶原膜的结构特性，以形成稳定的支架

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摘要

Application of restructured collagen-based biomaterials is generally restricted by their poor mechanical properties, which ideally must be close to those of a tissue being repaired. Here, we present an approach to the formation of a robust biomaterial using laser-induced curing of a photosensitive star-shaped polylactide. The created collagen-based structures demonstrated an increase in the Young's modulus by more than an order of magnitude with introduction of reinforcing patterns (from 0.15 +/- 0.02 MPa for the untreated collagen to 51.2 +/- 5.6 MPa for the reinforced collagen). It was shown that the geometrical configuration of the created reinforcing pattern affected the scaffold's mechanical properties only in the case of a relatively high laser radiation power density, when the effect of accumulated thermomechanical stresses in the photocured regions was significant. Photo-crosslinking of polylactide did not compromise the scaffold's cytotoxicity and provided fluorescent regions in the collagen matrix, that create a potential for noninvasive monitoring of such materials' biodegradation kinetics in vivo.
机译：重组胶原基生物材料的应用通常受到其较差的机械性能的限制，理想情况下，机械性能必须接近被修复组织的机械性能。在这里，我们提出了一种使用光敏星形聚丙交酯的激光诱导固化方法来形成坚固的生物材料的方法。产生的基于胶原的结构显示出通过引入增强图案（从未处理的胶原的0.15 +/- 0.02 MPa到增强的胶原的51.2 +/- 5.6 MPa），杨氏模量增加了一个数量级以上。结果表明，当光固化区域中累积的热机械应力的影响显着时，仅在相对较高的激光辐射功率密度的情况下，所产生的增强图案的几何构型才会影响支架的机械性能。聚丙交酯的光交联不会损害支架的细胞毒性，并在胶原蛋白基质中提供了荧光区域，这为无创监测此类材料的体内生物降解动力学创造了潜力。

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  • 来源
    《Materials science & engineering》 |2020年第2期|110300.1-110300.10|共10页
  • 作者

    Bardakova K. N.; Grebenik E. A.; Minaev N. V.; Churbanov S. N.; Moldagazyeva Z.; Krupinov G. E.; Kostjuk S. V.; Timashev P. S.;

  • 作者单位

    Sechenov Univ Inst Regenerat Med 8-2 Trubetskaya St Moscow 119991 Russia|Russian Acad Sci Res Ctr Crystallog & Photon Inst Photon Technol 2 Pionerskaya St Moscow 108840 Russia;

    Sechenov Univ Inst Regenerat Med 8-2 Trubetskaya St Moscow 119991 Russia;

    Russian Acad Sci Res Ctr Crystallog & Photon Inst Photon Technol 2 Pionerskaya St Moscow 108840 Russia;

    Almaty Technol Univ Chem Chem Technol & Ecol Dept Baytursynov St Alma Ata 050000 Kazakhstan;

    Sechenov Univ Inst Urol & Reprod Hlth 2-1 Bolshaya Pirogovskaya St Moscow 119435 Russia;

    Sechenov Univ Inst Regenerat Med 8-2 Trubetskaya St Moscow 119991 Russia|Belarusian State Univ Res Inst Phys Chem Problems 14 Leningradskaya St Minsk 220030 BELARUS|Belarusian State Univ Dept Chem 14 Leningradskaya St Minsk 220006 BELARUS;

    Sechenov Univ Inst Regenerat Med 8-2 Trubetskaya St Moscow 119991 Russia|Russian Acad Sci Res Ctr Crystallog & Photon Inst Photon Technol 2 Pionerskaya St Moscow 108840 Russia|Russian Acad Sci Semenov Inst Chem Phys 4 Kosygina St Moscow 119991 Russia;

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  • 正文语种 eng
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  • 关键词

    Collagen; Mechanical properties; Photopolymerization; Biocompatible polymers; Reinforcements; Riboflavin;

    机译：胶原;机械性能光聚合;生物相容性聚合物;增援;核黄素;

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