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首页> 外文期刊>Materials science & engineering >The effects of β-TCP on mechanical properties, corrosion behavior and biocompatibility of β-TCP/Zn-Mg composites
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The effects of β-TCP on mechanical properties, corrosion behavior and biocompatibility of β-TCP/Zn-Mg composites

机译：β-TCP对β-TCP/ Zn-Mg复合材料力学性能，腐蚀行为和生物相容性的影响

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摘要

Zinc has attracted increasing attention in the field of degradable implant materials due to its suitable degradation rate. To further improve the mechanical properties and biocompatibility of zinc, Zn-1Mg-nvol%beta-TCP (n = 0, 1, 3, 5) composites were fabricated for biomedical application by the mechanical stirring combined with ultrasonic assisted casting and hot extrusion technology. The microstructure, mechanical properties and corrosion behavior of these composites were systemically investigated and the composite with the best comprehensive performance were selected for biocompatibility evaluation including L-929 cells cytotoxicity test and SD rat model experiment. Tensile test revealed that Zn-1Mg-1vol%beta-TCP composite possessed optimal mechanical properties. The yield strength (YS), ultimate tensile strength (UTS), elongation (sigma) and elastic modulus (E) of the as-extruded Zn-1Mg-1vol%beta-TCP composite are 250.8 MPa, 330.5 MPa, 11.7% and 125.4 GPa respectively. The immersion tests showed that the corrosion resistance of the composite is slightly decreased with the increase of beta-TCP content. In addition, the addition of beta-TCP makes the cytocompatibility of the composites better than that of the Zn-1Mg alloy matrix. Various blood biochemical parameters in rat serum samples after implantation showed Zn-1Mg alloy and Zn-1Mg-beta-TCP composites has not significant tissue inflammation and showed good biocompatibility.
机译：锌由于其合适的降解速率而在可降解植入材料领域引起了越来越多的关注。为了进一步改善锌的机械性能和生物相容性，通过机械搅拌结合超声辅助浇铸和热挤压技术，制备了用于生物医学的Zn-1Mg-nvol％β-TCP（n = 0、1、3、5）复合材料。 。系统研究了这些复合材料的微观结构，力学性能和腐蚀行为，选择了综合性能最佳的复合材料进行生物相容性评价，包括L-929细胞的细胞毒性试验和SD大鼠模型实验。拉伸试验表明，Zn-1Mg-1vol％β-TCP复合材料具有最佳的力学性能。挤压后的Zn-1Mg-1vol％β-TCP复合材料的屈服强度（YS），极限抗拉强度（UTS），伸长率（σ）和弹性模量（E）分别为250.8 MPa，330.5 MPa，11.7％和125.4 GPa分别。浸渍试验表明，随着β-TCP含量的增加，复合材料的耐蚀性略有下降。此外，β-TCP的添加使复合材料的细胞相容性优于Zn-1Mg合金基体。植入后大鼠血清样品中的各种血液生化参数显示Zn-1Mg合金和Zn-1Mg-β-TCP复合材料没有明显的组织炎症，并显示出良好的生物相容性。

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