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首页> 外文期刊>Materials science & engineering >ZnO capped flower-like porous carbon-Fe_3O_4 composite as carrier for bi-triggered drug delivery
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ZnO capped flower-like porous carbon-Fe_3O_4 composite as carrier for bi-triggered drug delivery

机译：ZnO封端的花状多孔碳-Fe_3O_4复合材料为双触发药物输送的载体

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摘要

In this work, ZnO capped flower-like porous carbon-Fe3O4 composite (FPCS-Fe3O4-ZnO) was constructed as a carrier for pH and microwave bi-triggered drug delivery. In the composite, the FPCS achieves high-efficiency drug loading, the Fe3O4 acts as magnetic targeting agent and microwave absorption enhancer, and the ZnO nanoparticle as a sealing agent in response to pH stimulation. The carrier exhibited a flower-mesoporous sphere of 270 um, a specific surface area of 101 m(2)/g, a saturation magnetization of 14.08 emu/g, as well as good microwave thermal conversion properties (The temperature was raised from 25 degrees C to 60 degrees C only 24 s). Simultaneously, the carrier achieved an efficient drug loading with a drug loading rate of 99.1%. During the drug release experiments, obvious pH-dependent release behavior was observed, the drug release rate at 12 h was 8.2%, 19.0%, and 56.3% at pH 7.4, 5.0 and 3.0 respectively. Moreover the drug release rate increased from 8.2% to 39.9% after microwave stimulation at pH 7.4. In addition, cytotoxicity tests indicate that the carrier has good biocompatibility. Thus, this multifunctional pH and microwave bi-triggered carrier was expected to be further applied to drug delivery system(DDS).
机译：在这项工作中，构建了ZnO封端的花状多孔碳Fe3O4复合材料（FPCS-Fe3O4-ZnO）作为pH和微波双触发药物递送的载体。在复合材料中，FPCS实现了高效的药物负载，Fe3O4充当磁性靶向剂和微波吸收增强剂，而ZnO纳米颗粒作为响应pH刺激的密封剂。载体表现出270 um的花孔球形，比表面积101 m（2）/ g，饱和磁化强度14.08 emu / g以及良好的微波热转换性能（温度从25度升高C至60摄氏度仅24 s）。同时，载体达到了有效的载药量，载药率为99.1％。在药物释放实验中，观察到明显的pH依赖性释放行为，在pH 7.4、5.0和3.0时，在12 h时的药物释放速率分别为8.2％，19.0％和56.3％。此外，在pH 7.4的微波刺激下，药物释放速率从8.2％增加到39.9％。另外，细胞毒性测试表明载体具有良好的生物相容性。因此，预期该多功能pH和微波双触发载体将进一步应用于药物递送系统（DDS）。

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  • 来源
    《Materials science & engineering》 |2020年第2期|110256.1-110256.9|共9页
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    Northwest Univ Coll Chem & Mat Sci Key Lab Synthet & Nat Funct Mol Shaanxi Key Lab Phys Inorgan Chem Minist Educ Xian 710127 Shaanxi Peoples R China;

    Shaanxi Prov Inst Modern Agr Sci Xian 710068 Shaanxi Peoples R China;

    China Selenium Ind Res Inst Natl & Local Joint Engn Lab Selenium Enriched Foo Key Lab Seenriched Prod Dev & Qual Control Minist Agr Ankang 725000 Shaanxi Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Flower-like porous carbon; Surface modification; Microwave-triggered; pH-triggered; Drug release;

    机译：花状多孔碳;表面改性;微波触发;pH触发;药物释放;

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