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首页> 外文期刊>Materials science & engineering >Controlled release of cefazolin sodium antibiotic drug from electrospun chitosan-polyethylene oxide nanofibrous Mats
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Controlled release of cefazolin sodium antibiotic drug from electrospun chitosan-polyethylene oxide nanofibrous Mats

机译：从电纺制的壳聚糖-聚环氧乙烷纳米纤维垫中控制释放头孢唑林钠抗生素药物

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Antimicrobial electrospun chitosan-polyethylene oxide (CS-PEO) nanofibrous mats containing cefazolin, fumed silica (F. silica) and cefazolin-loaded fumed silica nanoparticles (NPs) were produced for biomedical applications. The FE-SEM images revealed that the F. silica and F. silica-cefazolin NPs had average diameters of 40 ± 10 and 60 ± 15 nm, respectively. Also, the fibers diameters were approximately 160 ± 30.90 ± 20 and 70 ± 15 nm for the pure CS-PEO, CS-PEO-1% F. silica and CS-PEO-1% F. silica-0.5% cefazolin nanofibrous mats, respectively indicating addition of F. silica and cefazolin loaded F. silica NPs to the CS-PEO mat led to decreasing the nanofiber diameter. Both of the CS-PEO mats containing 2.5% cefazolin and 1% F. silica-0.50% cefazolin showed 100% bactericidal activities against both S. aureus and E coli bacteria. The cefazolin release from mats was sharply increased within first 24 and 6 hours for the CS-PEO mats including 2.5% cefazolin and 1% F. silica-0.50% cefazolin but after that the drug was released very slowly. The improved hydrophilicity, higher tensile strength and sustained drug release for CS-PEO-1 % F. silica-0.50% cefazolin suggested that it was the best nanocomposite tissue/device for biomedical applications among the mats CS-PEO-2.5% cefazolin and CS-PEO-1% F. silica. The wound healing ability of the CS-PEO-F. silica-cefazolin mat was evaluated on the wounded skins of the female Wistar rats and it was shown that the wounded skins of the rats were almost entirely healed after ten days using this mat as a wound dressing scaffold.
机译：制备了包含头孢唑林，气相法二氧化硅（F.silica）和负载头孢唑林的气相法二氧化硅纳米粒子（NPs）的抗菌电纺丝壳聚糖-聚环氧乙烷（CS-PEO）纳米纤维垫。 FE-SEM图像显示二氧化硅硅藻土和纳米二氧化硅-头孢唑啉NP的平均直径分别为40±10和60±15 nm。同样，对于纯CS-PEO，CS-PEO-1％二氧化硅和CS-PEO-1％二氧化硅-0.5％头孢唑啉纳米纤维垫，纤维直径分别约为160±30.90±20和70±15 nm。分别表明将F.二氧化硅和头孢唑啉负载的F.二氧化硅NP添加至CS-PEO垫导致纳米纤维直径的减小。包含2.5％头孢唑啉和1％二氧化硅F-0.50％头孢唑啉的CS-PEO垫均显示出对金黄色葡萄球菌和大肠杆菌的100％杀菌活性。对于包含2.5％头孢唑林和1％硅酸0.50％头孢唑林的CS-PEO垫，头垫中头孢唑林的释放在最初的24和6小时内急剧增加，但此后药物释放非常缓慢。 CS-PEO-1％F.二氧化硅-0.50％头孢唑啉具有改善的亲水性，更高的拉伸强度和持续的药物释放，表明它是CS-PEO-2.5％头孢唑啉和CS垫中生物医学应用最佳的纳米复合组织/设备-PEO-1％二氧化硅。 CS-PEO-F的伤口愈合能力。在雌性Wistar大鼠的伤口皮肤上评估了二氧化硅-头孢唑啉垫，并且显示了使用该垫作为伤口敷料支架十天后，大鼠的伤口皮肤几乎完全愈合了。

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