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首页> 外文期刊>Materials science & engineering >Magneto-responsive liquid crystalline elastomer nanocomposites as potential candidates for dynamic cell culture substrates
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Magneto-responsive liquid crystalline elastomer nanocomposites as potential candidates for dynamic cell culture substrates

机译：磁响应液晶弹性体纳米复合材料可作为动态细胞培养基质的潜在候选材料

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摘要

Recently, liquid crystalline elastomers (LCEs) have been proposed as active substrates for cell culture due to their potential to attach and orient cells, and impose dynamic mechanical signals through the application of external stimuli. In this report, the preparation of anisotropic and oriented nematic magnetic-sensitized LCEs with iron oxide nanoparticles, and the evaluation of the effect of particle addition at low concentrations on the resultant structural, thermal, thermo-mechanical, and mechanical properties is presented. Phase transformations produced by heating in alternating magnetic fields were investigated in LCEs in contact with air, water, and a common liquid cell culture medium was also evaluated. The inclusion of nanoparticles into the elastomers displaced the nematic-to-isotropic phase transition, without affecting the nematic structure as evidenced by similar values of the order parameter, while reducing the maximum thermomechanical deformations. Remote and reversible deformations of the magnetic LCEs were achieved through the application of alternating magnetic fields, which induces the nematic-isotropic phase transition through nanoparticle heat generation. Formulation parameters can be modified to allow for remote actuation at values closer to the human physiological temperature range and within the range of deformations that can affect the cellular behavior of fibroblasts. Finally, a collagen surface treatment was performed to improve compatibility with N1H-3T3 fibroblast cultures, which enabled the attachment and proliferation of fibroblasts on substrates with and without magnetic particles under quiescent conditions. The LCEs developed in this work, which are able to deform and experience stress changes by remote contact-less magnetic stimulation, may allow for further studies on the effect of substrate morphology changes and dynamic mechanical properties during in vitro cell culture.
机译：近年来，由于液晶弹性体（LCE）具有附着和定向细胞的潜力，并已通过施加外部刺激施加动态机械信号，因此已提出将其用作细胞培养的活性基质。在此报告中，介绍了使用氧化铁纳米粒子制备各向异性取向的向列磁敏LCE，以及​​评估低浓度添加粒子对所得结构，热，热机械和机械性能的影响。在与空气，水接触的LCE中研究了在交变磁场中加热产生的相变，并且还评估了常见的液体细胞培养基。纳米粒子在弹性体中的夹杂物取代了向列相至各向同性的相变，而没有影响向列结构，这是由相似的阶数参数值所证实的，同时减少了最大的热机械变形。磁性LCE的远距离和可逆变形是通过施加交变磁场来实现的，该交变磁场通过纳米粒子的生热诱导向列各向同性相变。可以修改配方参数，以允许在更接近人体生理温度范围的值和可能影响成纤维细胞细胞行为的变形范围内进行远程致动。最后，进行胶原蛋白表面处理以改善与N1H-3T3成纤维细胞培养物的相容性，这使成纤维细胞在静止条件下有或没有磁性颗粒的基质上附着和增殖。在这项工作中开发的LCE能够通过远程无接触磁刺激而变形并经历应力变化，这可能允许进一步研究体外细胞培养过程中底物形态变化和动态力学性能的影响。

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  • 来源
    《Materials science & engineering》 |2016年第8期|369-378|共10页
  • 作者

    Stephany Herrera-Posada; Camilo Mora-Navarro; Patricia Ortiz-Bermudez; Madeline Torres-Lugo; Kyle M. McElhinny; Paul G. Evans; Barbara O. Calcagno; Aldo Acevedo;

  • 作者单位

    Department of Chemical Engineering, Call Box 9000, University of Puerto Rico, Mayagueez PR 00681, Puerto Rico;

    Department of Chemical Engineering, Call Box 9000, University of Puerto Rico, Mayagueez PR 00681, Puerto Rico;

    Department of Chemical Engineering, Call Box 9000, University of Puerto Rico, Mayagueez PR 00681, Puerto Rico;

    Department of Chemical Engineering, Call Box 9000, University of Puerto Rico, Mayagueez PR 00681, Puerto Rico;

    Department of Materials Science and Engineering, 1509 University Avenue, University of Wisconsin-Madison, WI 53706, USA;

    Department of Materials Science and Engineering, 1509 University Avenue, University of Wisconsin-Madison, WI 53706, USA;

    Department of General Engineering Call Box 9000, University of Puerto Rico, Mayagueez PR 00681, Puerto Rico;

    Department of Chemical Engineering, Call Box 9000, University of Puerto Rico, Mayagueez PR 00681, Puerto Rico;

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  • 正文语种 eng
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  • 关键词

    Liquid crystal elastomers; Actuation; Magnetic composites; Dynamic cell culture;

    机译：液晶弹性体;驱动;磁性复合材料;动态细胞培养;

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