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首页> 外文期刊>ACS Macro Letters >Electromechanically Responsive Liquid Crystal Elastomer Nanocomposites for Active Cell Culture
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Electromechanically Responsive Liquid Crystal Elastomer Nanocomposites for Active Cell Culture

机译：用于主动细胞培养的机电响应液晶弹性体纳米复合材料

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摘要

Liquid crystal elastomers (LCEs) are unique among shape-responsive materials in that they exhibit large and reversible shape changes and can respond to a variety of stimuli. However, only a handful of studies have explored LCEs for biomedical applications. Here, we demonstrate that LCE nanocomposites (LCE-NCs) exhibit a fast and reversible electromechanical response and can be employed as dynamic substrates for cell culture. A two-step method for preparing conductive LCE-NCs is described, which produces materials that exhibit rapid (response times as fast at 0.6 s), large-amplitude (contraction by up to 30%), and fully reversible shape changes (stable to over 5000 cycles) under externally applied voltages (5-40 V). The electromechanical response of the LCE-NCs is tunable through variation of the electrical potential and LCE-NC composition. We utilize conductive LCE-NCs as responsive substrates to culture neonatal rat ventricular myocytes (NRVM) and find that NRVM remain viable on both stimulated and static LCE-NC substrates. These materials provide a reliable and simple route to materials that exhibit a fast, reversible, and large-amplitude electromechanical response.
机译：液晶弹性体（LCE）在形状响应性材料中是独特的，因为它们表现出大而可逆的形状变化，并且可以对各种刺激做出响应。但是，只有少数研究探索了用于生物医学应用的LCE。在这里，我们证明LCE纳米复合材料（LCE-NCs）表现出快速和可逆的机电响应，可以用作细胞培养的动态底物。描述了一种制备导电LCE-NC的两步方法，该方法可生产出具有快速（响应时间快至0.6 s），大振幅（收缩率高达30％）和完全可逆的形状变化（稳定至超过5000个周期）在外部施加的电压（5-40 V）下。 LCE-NC的机电响应可通过电势和LCE-NC组成的变化进行调整。我们利用传导性LCE-NCs作为反应基质来培养新生大鼠心室肌细胞（NRVM），发现NRVM在受激和静态LCE-NC基质上均保持活力。这些材料为显示出快速，可逆和大幅度机电响应的材料提供了可靠而简单的途径。

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