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首页> 外文期刊>Materials science & engineering >Interaction of some cardiovascular drugs with bovine serum albumin at physiological conditions using glassy carbon electrode: A new approach
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Interaction of some cardiovascular drugs with bovine serum albumin at physiological conditions using glassy carbon electrode: A new approach

机译：玻碳电极在生理条件下某些心血管药物与牛血清白蛋白的相互作用：一种新方法

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摘要

In this report, for the first time, the non-modified glassy carbon electrode was used for detection of cardiovascular drug interaction with bovine serum albumin (BSA). These interactions were tested at physiological conditions (T = 37 ℃ and pH = 7.4 phosphate buffer solution) in different incubation times (0-4 h) by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV). The applications of DPV for quantitative investigation of some cardiovascular drug interaction with BSA (as a model of serum albumin proteins) were discussed. The herein described approach is expected to promote the exploitation of electrochemically-based methods for the study of drug-serum albumin protein interaction which is necessary in biochemical and biosensing studies. This report may open a new window to application of electrochemical sensors towards interactions of cardiovascular drugs with BSA and human serum albumin (HAS) in the near future.
机译：在本报告中，首次将未修饰的玻碳电极用于检测与牛血清白蛋白（BSA）的心血管药物相互作用。通过循环伏安法（CV），微分脉冲伏安法（DPV）和方波伏安法（SWV）在生理条件下（T = 37℃，pH = 7.4磷酸盐缓冲溶液）在不同的孵育时间（0-4小时）中测试了这些相互作用。讨论了DPV在定量研究某些与BSA（作为血清白蛋白蛋白模型）的心血管药物相互作用中的应用。预期本文描述的方法将促进基于电化学的方法用于研究药物-血清白蛋白相互作用的研究，这在生化和生物传感研究中是必需的。该报告可能在不久的将来为电化学传感器在心血管药物与BSA和人血清白蛋白（HAS）相互作用中的应用打开新的窗口。

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  • 来源
    《Materials science & engineering》 |2016年第8期|97-108|共12页
  • 作者

    Hadi Afsharan; Mohammad Hasanzadeh; Nasrin Shadjou; Abolghasem Jouyban;

  • 作者单位

    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran;

    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran,Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran;

    Department of Nanochemistry, Nano Technology Center and Faculty of Science, Urmia University, Urmia, Iran,Department of Chemistry, Faculty of Science, Urmia University, Urmia 57154, Iran;

    Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran;

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  • 正文语种 eng
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  • 关键词

    Bovine serum albumin; Cardiovascular drugs; Binding; Electrochemistry; Nano-science;

    机译：牛血清白蛋白;心血管药物;捆绑;电化学;纳米科学;

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